Spending on postapproval drug safety.

Journal Article (Journal Article)

Withdrawals of high-profile pharmaceuticals have focused attention on post-approval safety surveillance. There have been no systematic assessments of spending on postapproval safety. We surveyed drug manufacturers regarding safety efforts. Mean spending on postapproval safety per company in 2003 was 56 million dollars (0.3 percent of sales). Assuming a constant safety-to-sales ratio, we estimated that total spending on postapproval safety by the top twenty drug manufacturers was 800 million dollars in 2003. We also examined, using regression analysis, the relationship between the number of safety personnel and the number of initial adverse-event reports. This study offers information for the debate on proposed changes to safety surveillance.

Full Text

Duke Authors

Cited Authors

  • Ridley, DB; Kramer, JM; Tilson, HH; Grabowski, HG; Schulman, KA

Published Date

  • March 2006

Published In

Volume / Issue

  • 25 / 2

Start / End Page

  • 429 - 436

PubMed ID

  • 16522583

Electronic International Standard Serial Number (EISSN)

  • 1544-5208

Digital Object Identifier (DOI)

  • 10.1377/hlthaff.25.2.429


  • eng

Conference Location

  • United States