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Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project.

Publication ,  Journal Article
Clark, AG; Jordan, JM; Vilim, V; Renner, JB; Dragomir, AD; Luta, G; Kraus, VB
Published in: Arthritis Rheum
November 1999

OBJECTIVE: To characterize serum cartilage oligomeric matrix protein (COMP) levels by age and gender for a radiographically defined population free of hip and knee osteoarthritis (OA), and to examine the potential utility of COMP as a diagnostic biomarker for knee OA. METHODS: Serum samples and knee and hip radiographs were obtained at a baseline evaluation as part of the Johnston County Osteoarthritis Project, a population-based study of OA in rural North Carolina. A total of 291 Caucasian participants were randomly selected for COMP analysis, 143 patients with radiographic knee OA (Kellgren/Lawrence [K/L] grade > or = 2) and 148 controls with neither hip nor knee OA (K/L grade 0), evenly distributed by age and gender. COMP was quantified by competitive enzyme-linked immunosorbent assay with monoclonal antibody 17-C10. The natural log-transformed COMP data were analyzed using general linear models. RESULTS: Serum COMP levels were significantly elevated (P = 0.0001) in the age > or = 65 group (mean +/- SD 1,302.1 +/- 496.7 ng/ml) versus the age 45-54 and age 55-64 groups (1,058.1 +/- 432.4 and 1,038.6 +/- 313.3, respectively). Serum COMP levels of the OA group were significantly higher than those of the control group (1,208.57 +/- 487.47 ng/ml versus 1,061.83 +/- 370.58 ng/ml; P = 0.0093). Serum COMP levels also increased significantly with knee OA K/L grade (P = 0.0047), knee OA laterality (P = 0.0043), and number of knee and hip joints involved (P = 0.0001). There was no significant difference in serum COMP levels by gender or obesity. CONCLUSION: We demonstrate that in a population-based sample, serum COMP levels can distinguish an OA-affected subgroup from an unaffected subgroup and can reflect disease severity and multiple joint involvement in OA.

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Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

November 1999

Volume

42

Issue

11

Start / End Page

2356 / 2364

Location

United States

Related Subject Headings

  • Radiography
  • Osteoarthritis, Knee
  • Middle Aged
  • Matrilin Proteins
  • Male
  • Knee Joint
  • Humans
  • Hip Joint
  • Glycoproteins
  • Female
 

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Clark, A. G., Jordan, J. M., Vilim, V., Renner, J. B., Dragomir, A. D., Luta, G., & Kraus, V. B. (1999). Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project. Arthritis Rheum, 42(11), 2356–2364. https://doi.org/10.1002/1529-0131(199911)42:11<2356::AID-ANR14>3.0.CO;2-R
Clark, A. G., J. M. Jordan, V. Vilim, J. B. Renner, A. D. Dragomir, G. Luta, and V. B. Kraus. “Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project.Arthritis Rheum 42, no. 11 (November 1999): 2356–64. https://doi.org/10.1002/1529-0131(199911)42:11<2356::AID-ANR14>3.0.CO;2-R.
Clark AG, Jordan JM, Vilim V, Renner JB, Dragomir AD, Luta G, et al. Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project. Arthritis Rheum. 1999 Nov;42(11):2356–64.
Clark, A. G., et al. “Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project.Arthritis Rheum, vol. 42, no. 11, Nov. 1999, pp. 2356–64. Pubmed, doi:10.1002/1529-0131(199911)42:11<2356::AID-ANR14>3.0.CO;2-R.
Clark AG, Jordan JM, Vilim V, Renner JB, Dragomir AD, Luta G, Kraus VB. Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project. Arthritis Rheum. 1999 Nov;42(11):2356–2364.
Journal cover image

Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

November 1999

Volume

42

Issue

11

Start / End Page

2356 / 2364

Location

United States

Related Subject Headings

  • Radiography
  • Osteoarthritis, Knee
  • Middle Aged
  • Matrilin Proteins
  • Male
  • Knee Joint
  • Humans
  • Hip Joint
  • Glycoproteins
  • Female