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A study of anesthetic drug utilization in different age groups.

Publication ,  Journal Article
Martin, G; Glass, PSA; Breslin, DS; MacLeod, DB; Sanderson, IC; Lubarsky, DA; Reves, JG; Gan, TJ
Published in: J Clin Anesth
May 2003

STUDY OBJECTIVE: To determine anesthetic drug utilization in different age groups. DESIGN: Retrospective, automated, intraoperative database study. SETTING: Tertiary care medical center. MEASUREMENTS: 30,842 noncardiac general anesthesia case records between January 1991 and July 1997 were studied. We investigated the effect of age on anesthetic requirements for fentanyl (F), midazolam (M), thiopental sodium (T), propofol (P), isoflurane (I), and nitrous oxide (N). Because drugs are not given in isolation we looked at the most common drug combinations, IFNTM, IFNPM, INFT, and PFNM. Regression analyses on log-transformed drug dosages were used to test the significance of age on individual requirements. RESULTS: In each of the above anesthetic drug combinations, reduced doses of fentanyl, propofol, midazolam, thiopental, and isoflurane were used with increasing age. Fentanyl, propofol, thiopental, and isoflurane showed a 10%, 8%, 6%, and 4% reduction in dose per decade of age, respectively, from age of maximum dose to age 80 years. CONCLUSIONS: In clinical practice, increasing age results in decreased anesthetic drug administration. The mechanism of this observation needs to be determined.

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Published In

J Clin Anesth

DOI

ISSN

0952-8180

Publication Date

May 2003

Volume

15

Issue

3

Start / End Page

194 / 200

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Middle Aged
  • Male
  • Humans
  • Female
  • Drug Utilization
  • Drug Residues
  • Drug Combinations
  • Anesthetics, Intravenous
  • Anesthetics, Inhalation
 

Citation

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ICMJE
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Martin, G., Glass, P. S. A., Breslin, D. S., MacLeod, D. B., Sanderson, I. C., Lubarsky, D. A., … Gan, T. J. (2003). A study of anesthetic drug utilization in different age groups. J Clin Anesth, 15(3), 194–200. https://doi.org/10.1016/s0952-8180(03)00030-8
Martin, Gavin, Peter S. A. Glass, Dara S. Breslin, David B. MacLeod, Ian C. Sanderson, David A. Lubarsky, J. G. Reves, and Tong J. Gan. “A study of anesthetic drug utilization in different age groups.J Clin Anesth 15, no. 3 (May 2003): 194–200. https://doi.org/10.1016/s0952-8180(03)00030-8.
Martin G, Glass PSA, Breslin DS, MacLeod DB, Sanderson IC, Lubarsky DA, et al. A study of anesthetic drug utilization in different age groups. J Clin Anesth. 2003 May;15(3):194–200.
Martin, Gavin, et al. “A study of anesthetic drug utilization in different age groups.J Clin Anesth, vol. 15, no. 3, May 2003, pp. 194–200. Pubmed, doi:10.1016/s0952-8180(03)00030-8.
Martin G, Glass PSA, Breslin DS, MacLeod DB, Sanderson IC, Lubarsky DA, Reves JG, Gan TJ. A study of anesthetic drug utilization in different age groups. J Clin Anesth. 2003 May;15(3):194–200.
Journal cover image

Published In

J Clin Anesth

DOI

ISSN

0952-8180

Publication Date

May 2003

Volume

15

Issue

3

Start / End Page

194 / 200

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Middle Aged
  • Male
  • Humans
  • Female
  • Drug Utilization
  • Drug Residues
  • Drug Combinations
  • Anesthetics, Intravenous
  • Anesthetics, Inhalation