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The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the Bispectral Index.

Publication ,  Journal Article
Iselin-Chaves, IA; Flaishon, R; Sebel, PS; Howell, S; Gan, TJ; Sigl, J; Ginsberg, B; Glass, PS
Published in: Anesth Analg
October 1998

UNLABELLED: The Bispectral Index (BIS) correlates well with the level of consciousness with single anesthetic drugs. We studied the effect of the interaction of propofol with alfentanil on propofol concentration and BIS associated with 50% probability of loss of consciousness and lack of recall (Cp50 and BIS50, respectively). We studied 40 consenting volunteers at two institutions who were randomly assigned to receive stepped increases of propofol (10 subjects at each site), propofol plus alfentanil 50 ng/mL (10 subjects at Emory site), or propofol plus alfentanil 100 ng/mL (10 subjects at Duke site) by using a target-controlled infusion device. Measures of sedation, BIS, deltaBIS (absolute change of BIS after a painful stimulus), memory, and drug concentration were obtained at each target drug concentration. The relation among BIS, measured drug concentration, sedation score, and presence or absence of recall was determined by linear and logistic regression for different drug regimens, and the prediction probability (Pk) was calculated. The addition of alfentanil in increasing doses did not significantly affect the BIS50 and propofol Cp50 values for loss of consciousness and lack of recall. DeltaBIS was significantly decreased by both an increase in the concentration of propofol and the presence of alfentanil. The Pk for BIS was >0.93 with all drug regimens, better than those of the target and measured propofol concentrations. We conclude that BIS correlated well with the hypnotic component of anesthesia independent of the presence of an opioid. Moreover, the level of consciousness, and, therefore, the BIS index, is affected by a painful stimulus, and this response is ablated either by opioids or increasing propofol concentration. IMPLICATIONS: In volunteers, the sedation and changes in memory function produced by propofol correlated well with changes in the Bispectral Index. This relationship was not altered by the addition of an analgesic (alfentanil). However, in moderately sedated patients who received a painful stimulus, the Bispectral Index increased, but this response was blocked by the analgesic or increasing propofol concentrations.

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Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

October 1998

Volume

87

Issue

4

Start / End Page

949 / 955

Location

United States

Related Subject Headings

  • Signal Processing, Computer-Assisted
  • Prospective Studies
  • Propofol
  • Mental Recall
  • Male
  • Humans
  • Female
  • Electroencephalography
  • Drug Interactions
  • Consciousness
 

Citation

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Iselin-Chaves, I. A., Flaishon, R., Sebel, P. S., Howell, S., Gan, T. J., Sigl, J., … Glass, P. S. (1998). The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the Bispectral Index. Anesth Analg, 87(4), 949–955. https://doi.org/10.1097/00000539-199810000-00038
Iselin-Chaves, I. A., R. Flaishon, P. S. Sebel, S. Howell, T. J. Gan, J. Sigl, B. Ginsberg, and P. S. Glass. “The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the Bispectral Index.Anesth Analg 87, no. 4 (October 1998): 949–55. https://doi.org/10.1097/00000539-199810000-00038.
Iselin-Chaves IA, Flaishon R, Sebel PS, Howell S, Gan TJ, Sigl J, et al. The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the Bispectral Index. Anesth Analg. 1998 Oct;87(4):949–55.
Iselin-Chaves, I. A., et al. “The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the Bispectral Index.Anesth Analg, vol. 87, no. 4, Oct. 1998, pp. 949–55. Pubmed, doi:10.1097/00000539-199810000-00038.
Iselin-Chaves IA, Flaishon R, Sebel PS, Howell S, Gan TJ, Sigl J, Ginsberg B, Glass PS. The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the Bispectral Index. Anesth Analg. 1998 Oct;87(4):949–955.

Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

October 1998

Volume

87

Issue

4

Start / End Page

949 / 955

Location

United States

Related Subject Headings

  • Signal Processing, Computer-Assisted
  • Prospective Studies
  • Propofol
  • Mental Recall
  • Male
  • Humans
  • Female
  • Electroencephalography
  • Drug Interactions
  • Consciousness