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Changes in the auditory evoked potentials and the bispectral index following propofol or propofol and alfentanil.

Publication ,  Journal Article
Iselin-Chaves, IA; El Moalem, HE; Gan, TJ; Ginsberg, B; Glass, PS
Published in: Anesthesiology
May 2000

BACKGROUND: Midlatency auditory evoked potentials (MLAEP) show graded changes with increasing doses of hypnotics but little change with opioids. The effect of their combination on the MLAEP was evaluated. Also, the bispectral index (BIS) was compared with the ability of MLAEP to correlate with sedation and predict loss of consciousness. METHODS: Twenty healthy volunteers were randomly assigned to receive stepped increases in propofol concentration (10 subjects) or propofol plus alfentanil 100 ng/ml (10 subjects). At baseline and at each targeted effect site concentration the mean MLAEP, BIS, measures of sedation, and drug concentration were obtained. The relation among MLAEP, BIS, and sedation score was determined. The prediction probability (Pk) was calculated and compared for BIS and MLAEP. RESULTS: The BIS and MLAEP patterns showed significant changes (Pa and Nb decreased in amplitude and increased in latency) with increasing level of sedation (P < 0.0001). The BIS correlated better with sedation scores (0.884) than did the MLAEP (P < 0.05). Pa and Nb latencies showed the best correlation with sedation levels (0.685 and 0.658, respectively). The addition of alfentanil did not affect the relation between MLAEP and loss of consciousness (P > 0.15). The BIS (Pk = 0.952) was a better predictor of loss of consciousness than were Pa and Nb amplitude (P < 0.05) but were comparable to Pa and Nb latency (Pk = 0.869 and 0. 873, respectively). CONCLUSION: MLAEP changes, like the BIS, correlate well with increasing sedation produced by propofol, and these changes in the MLAEP are independent of the presence of an opioid. Among all the MLAEP parameters, Pa and Nb latencies are the best predictors of increasing sedation and loss of consciousness.

Duke Scholars

Published In

Anesthesiology

DOI

ISSN

0003-3022

Publication Date

May 2000

Volume

92

Issue

5

Start / End Page

1300 / 1310

Location

United States

Related Subject Headings

  • Prospective Studies
  • Propofol
  • Male
  • Logistic Models
  • Humans
  • Female
  • Evoked Potentials, Auditory
  • Electroencephalography
  • Drug Combinations
  • Conscious Sedation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Iselin-Chaves, I. A., El Moalem, H. E., Gan, T. J., Ginsberg, B., & Glass, P. S. (2000). Changes in the auditory evoked potentials and the bispectral index following propofol or propofol and alfentanil. Anesthesiology, 92(5), 1300–1310. https://doi.org/10.1097/00000542-200005000-00018
Iselin-Chaves, I. A., H. E. El Moalem, T. J. Gan, B. Ginsberg, and P. S. Glass. “Changes in the auditory evoked potentials and the bispectral index following propofol or propofol and alfentanil.Anesthesiology 92, no. 5 (May 2000): 1300–1310. https://doi.org/10.1097/00000542-200005000-00018.
Iselin-Chaves IA, El Moalem HE, Gan TJ, Ginsberg B, Glass PS. Changes in the auditory evoked potentials and the bispectral index following propofol or propofol and alfentanil. Anesthesiology. 2000 May;92(5):1300–10.
Iselin-Chaves, I. A., et al. “Changes in the auditory evoked potentials and the bispectral index following propofol or propofol and alfentanil.Anesthesiology, vol. 92, no. 5, May 2000, pp. 1300–10. Pubmed, doi:10.1097/00000542-200005000-00018.
Iselin-Chaves IA, El Moalem HE, Gan TJ, Ginsberg B, Glass PS. Changes in the auditory evoked potentials and the bispectral index following propofol or propofol and alfentanil. Anesthesiology. 2000 May;92(5):1300–1310.

Published In

Anesthesiology

DOI

ISSN

0003-3022

Publication Date

May 2000

Volume

92

Issue

5

Start / End Page

1300 / 1310

Location

United States

Related Subject Headings

  • Prospective Studies
  • Propofol
  • Male
  • Logistic Models
  • Humans
  • Female
  • Evoked Potentials, Auditory
  • Electroencephalography
  • Drug Combinations
  • Conscious Sedation