Comparison of the morphine-sparing effects of diclofenac sodium and ketorolac tromethamine after major orthopedic surgery.


Journal Article

STUDY OBJECTIVES:To compare the efficacy of diclofenac sodium with ketorolac tromethamine in reducing postoperative morphine use after major orthopedic surgery. DESIGN:Double-blind, randomized, placebo-controlled study. SETTING:Major teaching institution. PATIENTS:102 ASA physical status II patients undergoing hip and knee replacement with general anesthesia. INTERVENTIONS:Before induction of anesthesia, patients were randomly allocated to receive intravenously either diclofenac sodium 75 mg (Group D), ketorolac tromethamine 60 mg (Group K), or placebo (Group P). Patient-controlled analgesia was supplied postoperatively using morphine. MEASUREMENTS:Visual analog scale (VAS), verbal pain score (VPS), sedation score, frequency of opioid side effects, and morphine consumption were recorded every 4 hours. MAIN RESULTS:There was a highly significant downward trend for VAS, VPS, and sedation scores over time, p = 0.001. The mean VAS and VPS scores were significantly lower in Groups D and K compared with Group P at time 0, p = 0.009 and 8 hours, p = 0.026. The mean (SD) 24-hour morphine requirements were 36.3 mg (16.9), 47.2 mg (34.9), and 51.6 mg (22.2) for Groups D, K, and P, respectively, p = 0.032. Fewer patients suffered from postoperative nausea and vomiting in the treatment groups (Groups D and K) compared with Group P (9, 8, and 19, respectively), p < 0.05. Fewer patients also suffered from pruritus in Groups D and K compared with Group P (3, 4, and 11, respectively), p < 0.01. CONCLUSIONS:Preoperative administration of intravenous diclofenac 75 mg or ketorolac 60 mg significantly reduces morphine requirements and associated side effects after major orthopedic surgery.

Full Text

Cited Authors

  • Alexander, R; El-Moalem, HE; Gan, TJ

Published Date

  • May 2002

Published In

Volume / Issue

  • 14 / 3

Start / End Page

  • 187 - 192

PubMed ID

  • 12031750

Pubmed Central ID

  • 12031750

Electronic International Standard Serial Number (EISSN)

  • 1873-4529

International Standard Serial Number (ISSN)

  • 1873-4529

Digital Object Identifier (DOI)

  • 10.1016/s0952-8180(01)00382-8


  • eng