Measuring agreement between patient and proxy responses to multidimensional health-related quality-of-life measures in clinical trials. An application of psychometric profile analysis.

Journal Article (Journal Article)

When patients cannot provide responses to health-related quality-of-life (HRQOL) measures in clinical trials, family or friends may be asked to respond. We present a simple, comprehensive method for assessing agreement between patients with head injury and their proxy responders. In contrast to more traditional approaches, this method defines agreement separately for each patient-proxy pair, and compares HRQOL profiles along three dimensions-level, or the average of the ratings; scatter, or the variability in the ratings; and shape, or the ranks of the ratings. We demonstrate this method in the context of a clinical trial of a treatment for traumatic head injury and compare the results to those obtained using traditional analyses. Options for incorporating proxy responses into clinical trial analyses are discussed.

Full Text

Duke Authors

Cited Authors

  • Weinfurt, KP; Trucco, SM; Willke, RJ; Schulman, KA

Published Date

  • June 2002

Published In

Volume / Issue

  • 55 / 6

Start / End Page

  • 608 - 618

PubMed ID

  • 12063103

International Standard Serial Number (ISSN)

  • 0895-4356

Digital Object Identifier (DOI)

  • 10.1016/s0895-4356(02)00392-x


  • eng

Conference Location

  • United States