Bioelectrorheological model of the cell. 5. Electrodestruction of cellular membrane in alternating electric field

Journal Article

Recently proposed analysis of the extensil stress developed in a cellular membrane subjected to an alternating electric field (Pawlowski, P., and M. Fikus, 1993. Bioelectrorheological model of the cell. 4. Analysis of the extensil deformation of the membrane in an alternating electric field. Biophys. J. 65:535-540) was applied in calculations of extensil stress threshold values, σ0/(e)[d], producing experimentally observed electrodestruction of cells within the frequency range of 7 x 101 - 3 x 105 Hz. It was shown that the susceptibility (s[d] = 1/σ0/(e)[d]), of the membrane to this process varies with field frequency and depends on the type of cells. Electrodestruction is facilitated in the 105-Hz field. A rheological hypothesis explaining the experimentally observed dependence of membrane stability on electric field frequency was proposed and successfully tested for two other phenomena: electroporation and electrofusion.

Full Text

Duke Authors

Cited Authors

  • Pawlowski, P; Szutowicz, I; Marszalek, P; Fikus, M

Published Date

  • 1993

Published In

  • Biophysical Journal

Volume / Issue

  • 65 / 1

Start / End Page

  • 541 - 549

PubMed ID

  • 8369458

Digital Object Identifier (DOI)

  • 10.1016/S0006-3495(93)81056-7