Bioelectrorheological model of the cell. 5. Electrodestruction of cellular membrane in alternating electric field.

Journal Article (Journal Article)

Recently proposed analysis of the extensil stress developed in a cellular membrane subjected to an alternating electric field (Pawłowski, P., and M. Fikus, 1993. Bioelectrorheological model of the cell. 4. Analysis of the extensil deformation of the membrane in an alternating field. Biophys. J. 65:535-540) was applied in calculations of extensil stress threshold values, sigma eo[d], producing experimentally observed electrodestruction of cells within the frequency range of 7 x 10(1) - 3 x 10(5) Hz. It was shown that the susceptibility (s[d] = 1/sigma eo[d]), of the membrane to this process varies with field frequency and depends on the type of cells. Electrodestruction is facilitated in the 10(5)-Hz field. A rheological hypothesis explaining the experimentally observed dependence of membrane stability on electric field frequency was proposed and successfully tested for two other phenomena: electroporation and electrofusion.

Full Text

Duke Authors

Cited Authors

  • Pawłowski, P; Szutowicz, I; Marszałek, P; Fikus, M

Published Date

  • July 1993

Published In

Volume / Issue

  • 65 / 1

Start / End Page

  • 541 - 549

PubMed ID

  • 8369458

Pubmed Central ID

  • PMC1225747

Electronic International Standard Serial Number (EISSN)

  • 1542-0086

International Standard Serial Number (ISSN)

  • 0006-3495

Digital Object Identifier (DOI)

  • 10.1016/s0006-3495(93)81056-7


  • eng