Stretching single molecules into novel conformations using the atomic force microscope.


Journal Article (Review)

A dense network of interconnected proteins and carbohydrates forms the complex mechanical scaffold of living tissues. The recently developed technique of single molecule force spectroscopy using the atomic force microscope (AFM) has enabled a detailed analysis of the force-induced conformations of these molecules and the determinants of their mechanical stability. These studies provide some of the basic knowledge required to understand the mechanical interactions that define all biological organisms.

Full Text

Duke Authors

Cited Authors

  • Fisher, TE; Marszalek, PE; Fernandez, JM

Published Date

  • September 2000

Published In

Volume / Issue

  • 7 / 9

Start / End Page

  • 719 - 724

PubMed ID

  • 10966637

Pubmed Central ID

  • 10966637

International Standard Serial Number (ISSN)

  • 1072-8368

Digital Object Identifier (DOI)

  • 10.1038/78936


  • eng