Identification of sugar isomers by single-molecule force spectroscopy.


Journal Article

The nanomechanical properties of beta-galactan, a 1 --> 4 linked beta-d-galactose polysaccharide, were investigated with AFM-based single-molecule force spectroscopy. AFM captured a unique plateau at 640 pN in the force spectrogram of beta-galactan, which is significantly different than the plateau at 280 pN in the force spectrogram of amylose. Thus, our results demonstrate that force spectroscopy is able to discriminate between sugar isomers in which axial and equatorial bonds at C1 and C4 are swapped.

Full Text

Duke Authors

Cited Authors

  • Zhang, Q; Marszalek, PE

Published Date

  • May 2006

Published In

Volume / Issue

  • 128 / 17

Start / End Page

  • 5596 - 5597

PubMed ID

  • 16637601

Pubmed Central ID

  • 16637601

Electronic International Standard Serial Number (EISSN)

  • 1520-5126

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja058828e


  • eng