Acute adrenal insufficiency: a new presentation of Castleman's disease.
Publication
, Journal Article
Crump, JA; Beard, ME; Angus, HB; Fraser, R; Hart, DN; Nicholls, MG
Published in: J Intern Med
July 1995
We report the case of a 35-year-old patient who presented with acute adrenal insufficiency, then developed fever, hypoalbuminuria, anasarca, thrombocytopaenia and anaemia. Lymphadenopathy appeared later with microscopic features typical of Castleman's disease. Clinical remission followed treatment with intravenous immunoglobulin. Circulating interleukin-6 levels were elevated initially but were normal after immunoglobulin therapy. We surmise that high circulating levels of interleukin-6 (and ACTH) may have induced haemorrhagic necrosis of the adrenal glands and accounted for the constitutional symptoms.
Duke Scholars
Published In
J Intern Med
DOI
ISSN
0954-6820
Publication Date
July 1995
Volume
238
Issue
1
Start / End Page
81 / 84
Location
England
Related Subject Headings
- Male
- Interleukin-6
- Humans
- Diagnosis, Differential
- Castleman Disease
- Cardiovascular System & Hematology
- Adult
- Addison Disease
- Acute Disease
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Crump, J. A., Beard, M. E., Angus, H. B., Fraser, R., Hart, D. N., & Nicholls, M. G. (1995). Acute adrenal insufficiency: a new presentation of Castleman's disease. J Intern Med, 238(1), 81–84. https://doi.org/10.1111/j.1365-2796.1995.tb00903.x
Crump, J. A., M. E. Beard, H. B. Angus, R. Fraser, D. N. Hart, and M. G. Nicholls. “Acute adrenal insufficiency: a new presentation of Castleman's disease.” J Intern Med 238, no. 1 (July 1995): 81–84. https://doi.org/10.1111/j.1365-2796.1995.tb00903.x.
Crump JA, Beard ME, Angus HB, Fraser R, Hart DN, Nicholls MG. Acute adrenal insufficiency: a new presentation of Castleman's disease. J Intern Med. 1995 Jul;238(1):81–4.
Crump, J. A., et al. “Acute adrenal insufficiency: a new presentation of Castleman's disease.” J Intern Med, vol. 238, no. 1, July 1995, pp. 81–84. Pubmed, doi:10.1111/j.1365-2796.1995.tb00903.x.
Crump JA, Beard ME, Angus HB, Fraser R, Hart DN, Nicholls MG. Acute adrenal insufficiency: a new presentation of Castleman's disease. J Intern Med. 1995 Jul;238(1):81–84.
Published In
J Intern Med
DOI
ISSN
0954-6820
Publication Date
July 1995
Volume
238
Issue
1
Start / End Page
81 / 84
Location
England
Related Subject Headings
- Male
- Interleukin-6
- Humans
- Diagnosis, Differential
- Castleman Disease
- Cardiovascular System & Hematology
- Adult
- Addison Disease
- Acute Disease
- 1103 Clinical Sciences