Acute adrenal insufficiency: a new presentation of Castleman's disease.

Journal Article (Journal Article)

We report the case of a 35-year-old patient who presented with acute adrenal insufficiency, then developed fever, hypoalbuminuria, anasarca, thrombocytopaenia and anaemia. Lymphadenopathy appeared later with microscopic features typical of Castleman's disease. Clinical remission followed treatment with intravenous immunoglobulin. Circulating interleukin-6 levels were elevated initially but were normal after immunoglobulin therapy. We surmise that high circulating levels of interleukin-6 (and ACTH) may have induced haemorrhagic necrosis of the adrenal glands and accounted for the constitutional symptoms.

Full Text

Duke Authors

Cited Authors

  • Crump, JA; Beard, ME; Angus, HB; Fraser, R; Hart, DN; Nicholls, MG

Published Date

  • July 1995

Published In

Volume / Issue

  • 238 / 1

Start / End Page

  • 81 - 84

PubMed ID

  • 7608651

International Standard Serial Number (ISSN)

  • 0954-6820

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2796.1995.tb00903.x


  • eng

Conference Location

  • England