Genome-wide scan for Parkinson's disease: the GenePD Study.
A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine beta-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.
DeStefano, AL; Golbe, LI; Mark, MH; Lazzarini, AM; Maher, NE; Saint-Hilaire, M; Feldman, RG; Guttman, M; Watts, RL; Suchowersky, O; Lafontaine, AL; Labelle, N; Lew, MF; Waters, CH; Growdon, JH; Singer, C; Currie, LJ; Wooten, GF; Vieregge, P; Pramstaller, PP; Klein, C; Hubble, JP; Stacy, M; Montgomery, E; MacDonald, ME; Gusella, JF; Myers, RH
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