Genome-wide scan for Parkinson's disease: the GenePD Study.


Journal Article

A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine beta-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.

Full Text

Cited Authors

  • DeStefano, AL; Golbe, LI; Mark, MH; Lazzarini, AM; Maher, NE; Saint-Hilaire, M; Feldman, RG; Guttman, M; Watts, RL; Suchowersky, O; Lafontaine, AL; Labelle, N; Lew, MF; Waters, CH; Growdon, JH; Singer, C; Currie, LJ; Wooten, GF; Vieregge, P; Pramstaller, PP; Klein, C; Hubble, JP; Stacy, M; Montgomery, E; MacDonald, ME; Gusella, JF; Myers, RH

Published Date

  • September 2001

Published In

Volume / Issue

  • 57 / 6

Start / End Page

  • 1124 - 1126

PubMed ID

  • 11571351

Pubmed Central ID

  • 11571351

Electronic International Standard Serial Number (EISSN)

  • 1526-632X

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/wnl.57.6.1124


  • eng