The sensitivity and specificity of the 9-item Wearing-off Questionnaire.


Journal Article

OBJECTIVE: This multicenter, cross-sectional study was conducted to determine the sensitivity and specificity of a 9-item Wearing-off Questionnaire (WOQ-9) compared with assessment by a clinician. METHODS: Patients with a diagnosis of Parkinson's disease (PD) for 5 or=90 days, completed the WOQ-9 before independent evaluation by the physician. RESULTS: One hundred fifty-seven patients reported WO using the WOQ-9; only 79 had been previously diagnosed with WO by a physician. The most frequent items used by physicians to diagnose WO included type of symptoms (69.6%), symptom response (63.3%), and timing of symptom response (58.2%) to medication. Physician assessment of WO and WOQ-9 results corresponded in 76 of 79 cases; physicians disagreed with WO identification in 81 of 157 cases. Sensitivity of the WOQ-9 was 96.2% and specificity was 40.9%. CONCLUSION: The WOQ-9 is a useful screening tool to aid diagnosis of WO in PD patients.

Full Text

Cited Authors

  • Stacy, MA; Murphy, JM; Greeley, DR; Stewart, RM; Murck, H; Meng, X; COMPASS-I Study Investigators,

Published Date

  • January 2008

Published In

Volume / Issue

  • 14 / 3

Start / End Page

  • 205 - 212

PubMed ID

  • 17900967

Pubmed Central ID

  • 17900967

Electronic International Standard Serial Number (EISSN)

  • 1873-5126

International Standard Serial Number (ISSN)

  • 1353-8020

Digital Object Identifier (DOI)

  • 10.1016/j.parkreldis.2007.07.013


  • eng