Skip to main content

Bioaerosols and innate immune responses in airway diseases.

Publication ,  Journal Article
Hauswirth, DW; Sundy, JS
Published in: Curr Opin Allergy Clin Immunol
October 2004

PURPOSE OF REVIEW: We review the role of bioaerosols in the pathogenesis of inflammatory airway disease. The focus is on recent discoveries in innate immune responses induced by common components of bioaerosols. RECENT FINDINGS: Common components of bioaerosols include endotoxin, peptidoglycan and beta-glucan; all of which have been associated with inflammatory airway disease. Endotoxin signaling through toll-like receptor 4 is well characterized and updated. Peptidoglycan is now known to signal through three types of molecules: toll-like receptor 2; peptidoglycan recognition proteins; and nucleotide-binding oligomerization domain molecules. Beta-glucan, a common fungal cell wall component, signals through the newly discovered receptor, dectin-1. Emerging data indicate that genetic polymorphisms influence the response to bioaerosols. SUMMARY: Activation of the innate immune system by bioaerosols is becoming better understood. This knowledge provides an opportunity to better prevent and treat airway diseases that result from environmental exposure.

Duke Scholars

Published In

Curr Opin Allergy Clin Immunol

DOI

ISSN

1528-4050

Publication Date

October 2004

Volume

4

Issue

5

Start / End Page

361 / 366

Location

United States

Related Subject Headings

  • beta-Glucans
  • Pneumonia
  • Peptidoglycan
  • Immunity, Innate
  • Humans
  • Endotoxins
  • Allergy
  • Air Pollutants
  • Aerosols
  • 3204 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hauswirth, D. W., & Sundy, J. S. (2004). Bioaerosols and innate immune responses in airway diseases. Curr Opin Allergy Clin Immunol, 4(5), 361–366. https://doi.org/10.1097/00130832-200410000-00006
Hauswirth, David W., and John S. Sundy. “Bioaerosols and innate immune responses in airway diseases.Curr Opin Allergy Clin Immunol 4, no. 5 (October 2004): 361–66. https://doi.org/10.1097/00130832-200410000-00006.
Hauswirth DW, Sundy JS. Bioaerosols and innate immune responses in airway diseases. Curr Opin Allergy Clin Immunol. 2004 Oct;4(5):361–6.
Hauswirth, David W., and John S. Sundy. “Bioaerosols and innate immune responses in airway diseases.Curr Opin Allergy Clin Immunol, vol. 4, no. 5, Oct. 2004, pp. 361–66. Pubmed, doi:10.1097/00130832-200410000-00006.
Hauswirth DW, Sundy JS. Bioaerosols and innate immune responses in airway diseases. Curr Opin Allergy Clin Immunol. 2004 Oct;4(5):361–366.

Published In

Curr Opin Allergy Clin Immunol

DOI

ISSN

1528-4050

Publication Date

October 2004

Volume

4

Issue

5

Start / End Page

361 / 366

Location

United States

Related Subject Headings

  • beta-Glucans
  • Pneumonia
  • Peptidoglycan
  • Immunity, Innate
  • Humans
  • Endotoxins
  • Allergy
  • Air Pollutants
  • Aerosols
  • 3204 Immunology