Combination therapy for postoperative nausea and vomiting - a more effective prophylaxis?


Journal Article

The problem of postoperative nausea and vomiting (PONV) remains far from being resolved. Despite the introduction of new classes of antiemetics and a vast amount of published research, there is a general impression that there has been little progress in this area. The multifactorial etiology of PONV might be better addressed using a combination of drugs acting at different receptor sites. This approach of balanced antiemesis may be the answer towards achieving a significant improvement in the management of PONV. This article will cover the different strategies used to prevent PONV with particular emphasis on combination antiemetics. A review of the currently available methods to manage PONV as well as the physiological and pharmacological basis of combination therapy is presented.

Full Text

Duke Authors

Cited Authors

  • Habib, AS; Gan, TJ

Published Date

  • July 2001

Published In

Volume / Issue

  • 9 / 2

Start / End Page

  • 59 - 71

PubMed ID

  • 11454483

Pubmed Central ID

  • 11454483

International Standard Serial Number (ISSN)

  • 0966-6532


  • eng

Conference Location

  • Belgium