A randomized trial comparing acute normovolemic hemodilution and preoperative autologous blood donation in total hip arthroplasty.


Journal Article

BACKGROUND:The value of acute normovolemic hemodilution (ANH) as compared to preoperative autologous blood donation (PABD) in orthopedic surgery is unknown. Therefore, a prospective, randomized study was conducted to compare these techniques in patients undergoing primary total hip arthroplasty. STUDY DESIGN AND METHODS:ANH patients underwent phlebotomy for up to 3 units, or to a target Hct level of 28 percent after induction of anesthesia. PABD patients were asked to donate up to 3 units before admission. RESULTS:Mean baseline Hct levels were not different in ANH and PABD patients (39. 7 +/- 4.5 vs. 41.8 +/- 3.8%, p = 0.09). No difference was found in allogeneic blood exposure among ANH and PABD cohorts: 4 (17%) of 23 ANH patients received a total of 9 allogeneic blood units, compared to no allogeneic transfusions in the PABD cohort (p = 0.30). Total blood costs associated with ANH were significantly (p<0.05) lower than blood costs associated with PABD ($151 +/- 154 vs. $680 +/- 253, respectively). CONCLUSION:In patients undergoing total hip arthroplasty, ANH is safe, can be considered equivalent to PABD in effectively reducing exposure to allogeneic RBCs, and is less costly than PABD.

Full Text

Cited Authors

  • Goodnough, LT; Despotis, GJ; Merkel, K; Monk, TG

Published Date

  • September 2000

Published In

Volume / Issue

  • 40 / 9

Start / End Page

  • 1054 - 1057

PubMed ID

  • 10988305

Pubmed Central ID

  • 10988305

Electronic International Standard Serial Number (EISSN)

  • 1537-2995

International Standard Serial Number (ISSN)

  • 0041-1132

Digital Object Identifier (DOI)

  • 10.1046/j.1537-2995.2000.40091054.x


  • eng