Robust testing of haplotype/disease association.

Published online

Journal Article

Haplotypes, the combination of closely linked alleles that fall on the same chromosome, show great promise for studying the genetic components of complex diseases. However, when only multilocus genotype data are available, statistical approaches need to be employed to resolve haplotype phase ambiguity. Recently, we have proposed an approach to testing and estimating haplotype/disease association that is invariant to any existing genetic structure in the population. Here we evaluate this approach by applying it to the Genetic Analysis Workshop 14 simulated data.

Full Text

Duke Authors

Cited Authors

  • Allen, AS; Satten, GA

Published Date

  • December 30, 2005

Published In

Volume / Issue

  • 6 Suppl 1 /

Start / End Page

  • S69 -

PubMed ID

  • 16451682

Pubmed Central ID

  • 16451682

Electronic International Standard Serial Number (EISSN)

  • 1471-2156

Digital Object Identifier (DOI)

  • 10.1186/1471-2156-6-S1-S69

Language

  • eng

Conference Location

  • England