Bootstrap calibration of TRANSMIT for informative missingness of parental genotype data.

Published online

Journal Article

Informative missingness of parental genotype data occurs when the genotype of a parent influences the probability of the parent's genotype data being observed. Informative missingness can occur in a number of plausible ways and can affect both the validity and power of procedures that assume the data are missing at random (MAR). We propose a bootstrap calibration of MAR procedures to account for informative missingness and apply our methodology to refine the approach implemented in the TRANSMIT program. We illustrate this approach by applying it to data on hypertensive probands and their parents who participated in the Framingham Heart Study.

Full Text

Duke Authors

Cited Authors

  • Allen, AS; Collins, JS; Rathouz, PJ; Selander, CL; Satten, GA

Published Date

  • December 31, 2003

Published In

Volume / Issue

  • 4 Suppl 1 /

Start / End Page

  • S39 -

PubMed ID

  • 14975107

Electronic International Standard Serial Number (EISSN)

  • 1471-2156

Digital Object Identifier (DOI)

  • 10.1186/1471-2156-4-S1-S39

Language

  • eng

Conference Location

  • England