Propagation of fluctuations in biochemical systems, I: linear SSC networks.

Published

Journal Article

We investigate the propagation of random fluctuations through biochemical networks in which the number of molecules of each species is large enough so that the concentrations are well modeled by differential equations. We study the effect of network topology on the emergent properties of the reaction system by characterizing the behavior of variance as fluctuations propagate down chains and studying the effect of side chains and feedback loops. We also investigate the asymptotic behavior of the system as one reaction becomes fast relative to the others.

Full Text

Duke Authors

Cited Authors

  • Anderson, DF; Mattingly, JC; Nijhout, HF; Reed, MC

Published Date

  • August 2007

Published In

Volume / Issue

  • 69 / 6

Start / End Page

  • 1791 - 1813

PubMed ID

  • 17457656

Pubmed Central ID

  • 17457656

Electronic International Standard Serial Number (EISSN)

  • 1522-9602

International Standard Serial Number (ISSN)

  • 0092-8240

Digital Object Identifier (DOI)

  • 10.1007/s11538-007-9192-2

Language

  • eng