Human granulosa-luteal and cumulus cells express transforming growth factors-beta type 1 and type 2 mRNA.

Journal Article (Journal Article)

Human granulosa-luteal cells and cumulus cells obtained from women undergoing in vitro fertilization and embryo transfer (IVF-ET) were examined for the presence of TGF-beta 1 and TGF-beta 2 mRNA by reverse transcription-polymerase chain reaction (RT-PCR) analysis. RT-PCR analysis revealed that both follicle cell types express mRNA for both TGF-beta subtypes. Verification of RT-PCR products was done by restriction enzyme digestion analysis. These results suggest a role(s) for TGF-beta 1 and TGF-beta 2 in the development of human granulosa-luteal cells and the oocyte-cumulus cell complex.

Full Text

Duke Authors

Cited Authors

  • Mulheron, GW; Bossert, NL; Lapp, JA; Walmer, DK; Schomberg, DW

Published Date

  • February 1, 1992

Published In

Volume / Issue

  • 74 / 2

Start / End Page

  • 458 - 460

PubMed ID

  • 1370508

International Standard Serial Number (ISSN)

  • 0021-972X

Digital Object Identifier (DOI)

  • 10.1210/jcem.74.2.1370508


  • eng

Conference Location

  • United States