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Effects of aging on transient and sustained successful memory encoding activity.

Publication ,  Journal Article
Dennis, NA; Daselaar, S; Cabeza, R
Published in: Neurobiology of aging
November 2007

Event-related fMRI studies have investigated age-related changes in encoding by identifying greater activity for items that are later remembered than for those that are forgotten (difference in memory, or Dm). The present study used hybrid blocked/event-related analyses to distinguish between transient Dm versus sustained Dm. Dm was identified as parametric increases in encoding activity as a function of a combined subsequent memory/confidence scale. Dm was measured in each trial (transient activity) and in blocks of eight trials (sustained activity). Transient Dm analyses showed age-related reductions in the left hippocampus but increases in left prefrontal cortex (PFC). Sustained Dm analyses showed age-related reductions in right PFC, but no region showing increased activity in older adults. These findings suggests that during semantic classification older adults show less spontaneous hippocampal-mediated encoding processes, but greater PFC-mediated semantic processes. Additionally, the decline in sustained Dm in PFC may involve age-related deficits in sustained attention that impact encoding processes. The results underscore the importance of investigating aging effects on both transient and sustained neural activity.

Duke Scholars

Published In

Neurobiology of aging

DOI

EISSN

1558-1497

ISSN

0197-4580

Publication Date

November 2007

Volume

28

Issue

11

Start / End Page

1749 / 1758

Related Subject Headings

  • Reaction Time
  • Neurology & Neurosurgery
  • Middle Aged
  • Memory
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Aging
  • Aged
 

Citation

APA
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ICMJE
MLA
NLM
Dennis, N. A., Daselaar, S., & Cabeza, R. (2007). Effects of aging on transient and sustained successful memory encoding activity. Neurobiology of Aging, 28(11), 1749–1758. https://doi.org/10.1016/j.neurobiolaging.2006.07.006
Dennis, Nancy A., Sander Daselaar, and Roberto Cabeza. “Effects of aging on transient and sustained successful memory encoding activity.Neurobiology of Aging 28, no. 11 (November 2007): 1749–58. https://doi.org/10.1016/j.neurobiolaging.2006.07.006.
Dennis NA, Daselaar S, Cabeza R. Effects of aging on transient and sustained successful memory encoding activity. Neurobiology of aging. 2007 Nov;28(11):1749–58.
Dennis, Nancy A., et al. “Effects of aging on transient and sustained successful memory encoding activity.Neurobiology of Aging, vol. 28, no. 11, Nov. 2007, pp. 1749–58. Epmc, doi:10.1016/j.neurobiolaging.2006.07.006.
Dennis NA, Daselaar S, Cabeza R. Effects of aging on transient and sustained successful memory encoding activity. Neurobiology of aging. 2007 Nov;28(11):1749–1758.
Journal cover image

Published In

Neurobiology of aging

DOI

EISSN

1558-1497

ISSN

0197-4580

Publication Date

November 2007

Volume

28

Issue

11

Start / End Page

1749 / 1758

Related Subject Headings

  • Reaction Time
  • Neurology & Neurosurgery
  • Middle Aged
  • Memory
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Aging
  • Aged