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Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity.

Publication ,  Journal Article
Learn, CA; Grossi, PM; Schmittling, RJ; Xie, W; Mitchell, DA; Karikari, I; Wei, Z; Dressman, H; Sampson, JH
Published in: J Neuroimmunol
January 2007

For the study of malignant glioma, we have previously characterized a highly tumorigenic murine astrocytoma, SMA-560, which arose spontaneously in an inbred, immunocompetent VM/Dk mouse. Using this cell line as a model of murine glioma, we performed DNA microarray analysis of autologous normal murine astroctyes (NMA) and SMA-560 tumor cells grown in monolayer culture or intracranially in syngeneic immunocompetent or immunocompromised hosts in order to determine whether tumors grown in vitro recreate the complex genetic regulation that occurs in vivo. Our findings support our hypothesis that glioma phenotype in vitro may be quite different in vivo and significantly altered by in situ growth factors and other invading cell populations.

Duke Scholars

Published In

J Neuroimmunol

DOI

ISSN

0165-5728

Publication Date

January 2007

Volume

182

Issue

1-2

Start / End Page

63 / 72

Location

Netherlands

Related Subject Headings

  • T-Lymphocytes
  • Principal Component Analysis
  • Oligonucleotide Array Sequence Analysis
  • Neurology & Neurosurgery
  • Neoplasm Transplantation
  • Mice, Inbred BALB C
  • Mice
  • Immunocompromised Host
  • Immunocompetence
  • Immunity
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Learn, C. A., Grossi, P. M., Schmittling, R. J., Xie, W., Mitchell, D. A., Karikari, I., … Sampson, J. H. (2007). Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity. J Neuroimmunol, 182(1–2), 63–72. https://doi.org/10.1016/j.jneuroim.2006.09.016
Learn, Chris A., Peter M. Grossi, Robert J. Schmittling, Weihua Xie, Duane A. Mitchell, Isaac Karikari, ZhengZheng Wei, Holly Dressman, and John H. Sampson. “Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity.J Neuroimmunol 182, no. 1–2 (January 2007): 63–72. https://doi.org/10.1016/j.jneuroim.2006.09.016.
Learn CA, Grossi PM, Schmittling RJ, Xie W, Mitchell DA, Karikari I, et al. Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity. J Neuroimmunol. 2007 Jan;182(1–2):63–72.
Learn, Chris A., et al. “Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity.J Neuroimmunol, vol. 182, no. 1–2, Jan. 2007, pp. 63–72. Pubmed, doi:10.1016/j.jneuroim.2006.09.016.
Learn CA, Grossi PM, Schmittling RJ, Xie W, Mitchell DA, Karikari I, Wei Z, Dressman H, Sampson JH. Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity. J Neuroimmunol. 2007 Jan;182(1–2):63–72.
Journal cover image

Published In

J Neuroimmunol

DOI

ISSN

0165-5728

Publication Date

January 2007

Volume

182

Issue

1-2

Start / End Page

63 / 72

Location

Netherlands

Related Subject Headings

  • T-Lymphocytes
  • Principal Component Analysis
  • Oligonucleotide Array Sequence Analysis
  • Neurology & Neurosurgery
  • Neoplasm Transplantation
  • Mice, Inbred BALB C
  • Mice
  • Immunocompromised Host
  • Immunocompetence
  • Immunity