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Relaxed selection among duplicate floral regulatory genes in Lamiales.

Publication ,  Journal Article
Aagaard, JE; Willis, JH; Phillips, PC
Published in: Journal of molecular evolution
October 2006

Polyploidization is a prevalent mode of genome diversification within plants. Most gene duplicates arising from polyploidization (paralogs) are typically lost, although a subset may be maintained under selection due to dosage, partitioning of gene function, or acquisition of novel functions. Because they experience selection in the presence of other duplicate loci across the genome, interactions among genes may also play a significant role in the maintenance of paralogs resulting from polyploidization. Previously, we identified duplicates of the genes LFY/FLO and AP3/DEF that directly interact in a floral regulatory pathway and are thought to be the result of ancient polyploidization in the Lamiales (> 50 mya). Although duplicates of MADS box genes including AP3/DEF are common throughout the angiosperm lineage, LFY/FLO duplicates in Lamiales are the first reported outside of tetraploid taxa. In order to explore hypotheses for the joint preservation of these interacting floral regulatory genes including novel LFY/FLO paralogs, here we clone FLO and DEF duplicates from additional Lamiales taxa and apply codon substitution models to test how selection acts on both genes following duplication. We find acceleration in the ratio of nonsynonymous-to-synonymous nucleotide substitutions for one (FLO) or both (DEF) paralogs that appears to be due to relaxed purifying selection as opposed to positive selection and shows a different pattern among functional domains of these genes. Several mechanisms are discussed that might be responsible for preservation of co-orthologs of FLO and DEF in Lamiales, including interactions among the genes of this regulatory pathway.

Duke Scholars

Published In

Journal of molecular evolution

DOI

EISSN

1432-1432

ISSN

0022-2844

Publication Date

October 2006

Volume

63

Issue

4

Start / End Page

493 / 503

Related Subject Headings

  • Selection, Genetic
  • Protein Structure, Tertiary
  • Phylogeny
  • Magnoliopsida
  • Genetic Variation
  • Genes, Regulator
  • Genes, Plant
  • Gene Duplication
  • Flowers
  • Evolutionary Biology
 

Citation

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Aagaard, J. E., Willis, J. H., & Phillips, P. C. (2006). Relaxed selection among duplicate floral regulatory genes in Lamiales. Journal of Molecular Evolution, 63(4), 493–503. https://doi.org/10.1007/s00239-005-0306-x
Aagaard, Jan E., John H. Willis, and Patrick C. Phillips. “Relaxed selection among duplicate floral regulatory genes in Lamiales.Journal of Molecular Evolution 63, no. 4 (October 2006): 493–503. https://doi.org/10.1007/s00239-005-0306-x.
Aagaard JE, Willis JH, Phillips PC. Relaxed selection among duplicate floral regulatory genes in Lamiales. Journal of molecular evolution. 2006 Oct;63(4):493–503.
Aagaard, Jan E., et al. “Relaxed selection among duplicate floral regulatory genes in Lamiales.Journal of Molecular Evolution, vol. 63, no. 4, Oct. 2006, pp. 493–503. Epmc, doi:10.1007/s00239-005-0306-x.
Aagaard JE, Willis JH, Phillips PC. Relaxed selection among duplicate floral regulatory genes in Lamiales. Journal of molecular evolution. 2006 Oct;63(4):493–503.
Journal cover image

Published In

Journal of molecular evolution

DOI

EISSN

1432-1432

ISSN

0022-2844

Publication Date

October 2006

Volume

63

Issue

4

Start / End Page

493 / 503

Related Subject Headings

  • Selection, Genetic
  • Protein Structure, Tertiary
  • Phylogeny
  • Magnoliopsida
  • Genetic Variation
  • Genes, Regulator
  • Genes, Plant
  • Gene Duplication
  • Flowers
  • Evolutionary Biology