Paecilomyces varioti endocarditis on a prosthetic aortic valve.

Journal Article (Journal Article)

Fungal endocarditis following prosthetic valve surgery has assumed increased importance as a cause of postoperative death. We present, to our knowledge, the first case of the fungus Paecilomyces varioti producing endocarditis on a prosthetic aortic valve. This seems to be an extremely indolent organism which exhibits an apparent response to antibiotic therapyl. In vitro evidence suggests that this fungus is sensitive to attainable serum levels of both 5-fluorocytosine and amphotericin B. However, after viewing the extracted valve and the devastating embolic phenomenon in our patient, we believe that medical therapy alone would not suffice. Thus we suggest that prompt valve replacement be performed in future cases.

Full Text

Duke Authors

Cited Authors

  • McClellan, JR; Hamilton, JD; Alexander, JA; Wolfe, WG; Reed, JB

Published Date

  • March 1, 1976

Published In

Volume / Issue

  • 71 / 3

Start / End Page

  • 472 - 475

PubMed ID

  • 943032

Pubmed Central ID

  • 943032

International Standard Serial Number (ISSN)

  • 0022-5223


  • eng

Conference Location

  • United States