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Paecilomyces varioti endocarditis on a prosthetic aortic valve.

Publication ,  Journal Article
McClellan, JR; Hamilton, JD; Alexander, JA; Wolfe, WG; Reed, JB
Published in: J Thorac Cardiovasc Surg
March 1976

Fungal endocarditis following prosthetic valve surgery has assumed increased importance as a cause of postoperative death. We present, to our knowledge, the first case of the fungus Paecilomyces varioti producing endocarditis on a prosthetic aortic valve. This seems to be an extremely indolent organism which exhibits an apparent response to antibiotic therapyl. In vitro evidence suggests that this fungus is sensitive to attainable serum levels of both 5-fluorocytosine and amphotericin B. However, after viewing the extracted valve and the devastating embolic phenomenon in our patient, we believe that medical therapy alone would not suffice. Thus we suggest that prompt valve replacement be performed in future cases.

Duke Scholars

Published In

J Thorac Cardiovasc Surg

ISSN

0022-5223

Publication Date

March 1976

Volume

71

Issue

3

Start / End Page

472 / 475

Location

United States

Related Subject Headings

  • Thrombosis
  • Respiratory System
  • Mycoses
  • Mitosporic Fungi
  • Middle Aged
  • Male
  • Humans
  • Heart Valve Prosthesis
  • Endocarditis
  • Aortic Valve Insufficiency
 

Citation

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McClellan, J. R., Hamilton, J. D., Alexander, J. A., Wolfe, W. G., & Reed, J. B. (1976). Paecilomyces varioti endocarditis on a prosthetic aortic valve. J Thorac Cardiovasc Surg, 71(3), 472–475.
McClellan, J. R., J. D. Hamilton, J. A. Alexander, W. G. Wolfe, and J. B. Reed. “Paecilomyces varioti endocarditis on a prosthetic aortic valve.J Thorac Cardiovasc Surg 71, no. 3 (March 1976): 472–75.
McClellan JR, Hamilton JD, Alexander JA, Wolfe WG, Reed JB. Paecilomyces varioti endocarditis on a prosthetic aortic valve. J Thorac Cardiovasc Surg. 1976 Mar;71(3):472–5.
McClellan, J. R., et al. “Paecilomyces varioti endocarditis on a prosthetic aortic valve.J Thorac Cardiovasc Surg, vol. 71, no. 3, Mar. 1976, pp. 472–75.
McClellan JR, Hamilton JD, Alexander JA, Wolfe WG, Reed JB. Paecilomyces varioti endocarditis on a prosthetic aortic valve. J Thorac Cardiovasc Surg. 1976 Mar;71(3):472–475.
Journal cover image

Published In

J Thorac Cardiovasc Surg

ISSN

0022-5223

Publication Date

March 1976

Volume

71

Issue

3

Start / End Page

472 / 475

Location

United States

Related Subject Headings

  • Thrombosis
  • Respiratory System
  • Mycoses
  • Mitosporic Fungi
  • Middle Aged
  • Male
  • Humans
  • Heart Valve Prosthesis
  • Endocarditis
  • Aortic Valve Insufficiency