Structural equation modeling and nested ANOVA: effects of lead exposure on maternal and fetal growth in rats.

Journal Article

This study provided an assessment of the effects of lead on early growth in rats based on structural equation modeling and nested analysis of variance (ANOVA). Structural equation modeling showed that lead in drinking water (250, 500, or 1000 ppm) had a direct negative effect on body weight and tail length (i.e., growth) in female rats during the first week of exposure. During the following 2 weeks of exposure, high correlation between growth measurements taken over time resulted in reduced early postnatal growth. By the fourth week of exposure, reduced growth was not evident. Mating began after 8 weeks of exposure, and exposure continued during gestation. Decreased fetal body weight was detected when the effects of litter size, intrauterine position, and sex were controlled in a nested ANOVA. Lead exposure did not appear to affect fetal skeletal development, possibly because lead did not alter maternal serum calcium and phosphorus levels. The effect of lead on individual fetal body weight suggests that additional studies are needed to examine the effect of maternal lead exposure on fetal development and early postnatal growth.

Full Text

Duke Authors

Cited Authors

  • Hamilton, JD; O'Flaherty, EJ; Ross, R; Shukla, R; Gartside, PS

Published Date

  • January 1994

Published In

Volume / Issue

  • 64 / 1

Start / End Page

  • 53 - 64

PubMed ID

  • 8287842

International Standard Serial Number (ISSN)

  • 0013-9351

Language

  • eng

Conference Location

  • Netherlands