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Endoplasmic reticulum stress.

Publication ,  Journal Article
Bánhegyi, G; Baumeister, P; Benedetti, A; Dong, D; Fu, Y; Lee, AS; Li, J; Mao, C; Margittai, E; Ni, M; Paschen, W; Piccirella, S; Senesi, S ...
Published in: Ann N Y Acad Sci
October 2007

Stress is the imbalance of homeostasis, which can be sensed even at the subcellular level. The stress-sensing capability of various organelles including the endoplasmic reticulum (ER) has been described. It has become evident that acute or prolonged ER stress plays an important role in many human diseases; especially those involving organs/tissues specialized in protein secretion. This article summarizes the emerging role of ER stress in diverse human pathophysiological conditions such as carcinogenesis and tumor progression, cerebral ischemia, plasma cell maturation and apoptosis, obesity, insulin resistance, and type 2 diabetes. Certain components of the ER stress response machinery are identified as biomarkers of the diseases or as possible targets for therapeutic intervention.

Duke Scholars

Published In

Ann N Y Acad Sci

DOI

ISSN

0077-8923

Publication Date

October 2007

Volume

1113

Start / End Page

58 / 71

Location

United States

Related Subject Headings

  • Molecular Chaperones
  • Humans
  • Heat-Shock Response
  • Heat-Shock Proteins
  • General Science & Technology
  • Endoplasmic Reticulum Chaperone BiP
  • Endoplasmic Reticulum
  • Animals
 

Citation

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Bánhegyi, G., Baumeister, P., Benedetti, A., Dong, D., Fu, Y., Lee, A. S., … Yang, W. (2007). Endoplasmic reticulum stress. Ann N Y Acad Sci, 1113, 58–71. https://doi.org/10.1196/annals.1391.007
Bánhegyi, Gábor, Peter Baumeister, Angelo Benedetti, Dezheng Dong, Yong Fu, Amy S. Lee, Jianze Li, et al. “Endoplasmic reticulum stress.Ann N Y Acad Sci 1113 (October 2007): 58–71. https://doi.org/10.1196/annals.1391.007.
Bánhegyi G, Baumeister P, Benedetti A, Dong D, Fu Y, Lee AS, et al. Endoplasmic reticulum stress. Ann N Y Acad Sci. 2007 Oct;1113:58–71.
Bánhegyi, Gábor, et al. “Endoplasmic reticulum stress.Ann N Y Acad Sci, vol. 1113, Oct. 2007, pp. 58–71. Pubmed, doi:10.1196/annals.1391.007.
Bánhegyi G, Baumeister P, Benedetti A, Dong D, Fu Y, Lee AS, Li J, Mao C, Margittai E, Ni M, Paschen W, Piccirella S, Senesi S, Sitia R, Wang M, Yang W. Endoplasmic reticulum stress. Ann N Y Acad Sci. 2007 Oct;1113:58–71.
Journal cover image

Published In

Ann N Y Acad Sci

DOI

ISSN

0077-8923

Publication Date

October 2007

Volume

1113

Start / End Page

58 / 71

Location

United States

Related Subject Headings

  • Molecular Chaperones
  • Humans
  • Heat-Shock Response
  • Heat-Shock Proteins
  • General Science & Technology
  • Endoplasmic Reticulum Chaperone BiP
  • Endoplasmic Reticulum
  • Animals