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Multi-step control of spindle pole body duplication by cyclin-dependent kinase.

Publication ,  Journal Article
Haase, SB; Winey, M; Reed, SI
Published in: Nature cell biology
January 2001

Organelles called centrosomes in metazoans or spindle pole bodies (SPBs) in yeast direct the assembly of a bipolar spindle that is essential for faithful segregation of chromosomes during mitosis. Abnormal accumulation of multiple centrosomes leads to genome instability, and has been observed in both tumour cells and cells with targeted mutations in tumour-suppressor genes. The defects that lead to centrosome amplification are not understood. We have recapitulated the multiple-centrosome phenotype in budding yeast by disrupting the activity of specific cyclin-dependent kinase (CDK) complexes. Our observations are reminiscent of mechanisms that govern DNA replication, and show that specific cyclin/CDK activities function both to promote SPB duplication and to prevent SPB reduplication.

Duke Scholars

Published In

Nature cell biology

DOI

EISSN

1476-4679

ISSN

1465-7392

Publication Date

January 2001

Volume

3

Issue

1

Start / End Page

38 / 42

Related Subject Headings

  • Yeasts
  • Spindle Apparatus
  • Saccharomyces cerevisiae Proteins
  • Mitosis
  • Developmental Biology
  • Cyclins
  • Cyclin-Dependent Kinases
  • Cyclin B
  • Centrosome
  • Cell Transformation, Neoplastic
 

Citation

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MLA
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Haase, S. B., Winey, M., & Reed, S. I. (2001). Multi-step control of spindle pole body duplication by cyclin-dependent kinase. Nature Cell Biology, 3(1), 38–42. https://doi.org/10.1038/35050543
Haase, S. B., M. Winey, and S. I. Reed. “Multi-step control of spindle pole body duplication by cyclin-dependent kinase.Nature Cell Biology 3, no. 1 (January 2001): 38–42. https://doi.org/10.1038/35050543.
Haase SB, Winey M, Reed SI. Multi-step control of spindle pole body duplication by cyclin-dependent kinase. Nature cell biology. 2001 Jan;3(1):38–42.
Haase, S. B., et al. “Multi-step control of spindle pole body duplication by cyclin-dependent kinase.Nature Cell Biology, vol. 3, no. 1, Jan. 2001, pp. 38–42. Epmc, doi:10.1038/35050543.
Haase SB, Winey M, Reed SI. Multi-step control of spindle pole body duplication by cyclin-dependent kinase. Nature cell biology. 2001 Jan;3(1):38–42.

Published In

Nature cell biology

DOI

EISSN

1476-4679

ISSN

1465-7392

Publication Date

January 2001

Volume

3

Issue

1

Start / End Page

38 / 42

Related Subject Headings

  • Yeasts
  • Spindle Apparatus
  • Saccharomyces cerevisiae Proteins
  • Mitosis
  • Developmental Biology
  • Cyclins
  • Cyclin-Dependent Kinases
  • Cyclin B
  • Centrosome
  • Cell Transformation, Neoplastic