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Beta adrenergic receptors in lymphocyte subpopulations.

Publication ,  Journal Article
Bishopric, NH; Cohen, HJ; Lefkowitz, RJ
Published in: J Allergy Clin Immunol
January 1980

To further evaluate the potential utility of lymphocyte beta adrenergic receptor assays in the study of receptor alterations in human disease, we studied highly purified populations of B and T lymphocytes in peripheral blood to see if differences existed in the concentration or affinity of beta adrenergic receptors and catecholamine-responsive cAMP levels. The mean number of receptors present in particulate fractions of B cells did not differ significantly from the number found in T cells. Similarly, no significant difference in the dissociation constant for (-)[3H]dihydroalprenolol was found. Cyclic adenosine monophosphate (cAMP) accumulation in whole lymphocytes as measured by radioimmunoassay was comparable, although a tendency toward lower basal and stimulated levels in the T cells was evident. The data suggest that differences observed in concentrations of beta adrenergic receptors or catecholamine-responsive cAMP accumulation in lymphocytes from patients with varying illnesses are not likely to be due to differences in the proportions of circulating B and T lymphocytes.

Duke Scholars

Published In

J Allergy Clin Immunol

DOI

ISSN

0091-6749

Publication Date

January 1980

Volume

65

Issue

1

Start / End Page

29 / 33

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic
  • Propranolol
  • Male
  • Lymphocytes
  • Isoproterenol
  • Humans
  • Female
  • Dihydroalprenolol
 

Citation

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Bishopric, N. H., Cohen, H. J., & Lefkowitz, R. J. (1980). Beta adrenergic receptors in lymphocyte subpopulations. J Allergy Clin Immunol, 65(1), 29–33. https://doi.org/10.1016/0091-6749(80)90173-6
Bishopric, N. H., H. J. Cohen, and R. J. Lefkowitz. “Beta adrenergic receptors in lymphocyte subpopulations.J Allergy Clin Immunol 65, no. 1 (January 1980): 29–33. https://doi.org/10.1016/0091-6749(80)90173-6.
Bishopric NH, Cohen HJ, Lefkowitz RJ. Beta adrenergic receptors in lymphocyte subpopulations. J Allergy Clin Immunol. 1980 Jan;65(1):29–33.
Bishopric, N. H., et al. “Beta adrenergic receptors in lymphocyte subpopulations.J Allergy Clin Immunol, vol. 65, no. 1, Jan. 1980, pp. 29–33. Pubmed, doi:10.1016/0091-6749(80)90173-6.
Bishopric NH, Cohen HJ, Lefkowitz RJ. Beta adrenergic receptors in lymphocyte subpopulations. J Allergy Clin Immunol. 1980 Jan;65(1):29–33.
Journal cover image

Published In

J Allergy Clin Immunol

DOI

ISSN

0091-6749

Publication Date

January 1980

Volume

65

Issue

1

Start / End Page

29 / 33

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic
  • Propranolol
  • Male
  • Lymphocytes
  • Isoproterenol
  • Humans
  • Female
  • Dihydroalprenolol