Prednisone-responsive aplastic anemia associated with T-lymphocyte proliferation.

Journal Article (Journal Article)

In some cases, bone marrow aplasia has been thought to result from immunologic abnormalities. Our patient had severe transfusion-dependent aplastic anemia, which responded to treatment with prednisone on two occasions. The exacerbations of aplastic anemia were associated with lymphocytic proliferation which on one occasion had the characteristics of T-cell chronic lymphocytic leukemia. Though he had had mild lymphoproliferation for a number of years, he ultimately died with progressive diffuse lymphoid infiltration of the bone marrow and other organs. The simultaneous occurrence of the T-cell lymphoproliferation and aplastic anemia and their simultaneous response to therapy suggests that this may be a clinical example of T-lymphocyte mediated suppression of erythropoiesis.

Full Text

Duke Authors

Cited Authors

  • Bodner, S; Cohen, HJ

Published Date

  • November 1, 1981

Published In

Volume / Issue

  • 11 / 3

Start / End Page

  • 293 - 298

PubMed ID

  • 6976120

International Standard Serial Number (ISSN)

  • 0361-8609

Digital Object Identifier (DOI)

  • 10.1002/ajh.2830110310


  • eng

Conference Location

  • United States