Prednisone-responsive aplastic anemia associated with T-lymphocyte proliferation.
In some cases, bone marrow aplasia has been thought to result from immunologic abnormalities. Our patient had severe transfusion-dependent aplastic anemia, which responded to treatment with prednisone on two occasions. The exacerbations of aplastic anemia were associated with lymphocytic proliferation which on one occasion had the characteristics of T-cell chronic lymphocytic leukemia. Though he had had mild lymphoproliferation for a number of years, he ultimately died with progressive diffuse lymphoid infiltration of the bone marrow and other organs. The simultaneous occurrence of the T-cell lymphoproliferation and aplastic anemia and their simultaneous response to therapy suggests that this may be a clinical example of T-lymphocyte mediated suppression of erythropoiesis.
Duke Scholars
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Related Subject Headings
- T-Lymphocytes
- Splenomegaly
- Prednisone
- Platelet Count
- Lymphocytes
- Lymphocyte Activation
- Leukocyte Count
- Immunology
- Humans
- Hepatomegaly
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- T-Lymphocytes
- Splenomegaly
- Prednisone
- Platelet Count
- Lymphocytes
- Lymphocyte Activation
- Leukocyte Count
- Immunology
- Humans
- Hepatomegaly