Prednisone-responsive aplastic anemia associated with T-lymphocyte proliferation.
Journal Article (Journal Article)
In some cases, bone marrow aplasia has been thought to result from immunologic abnormalities. Our patient had severe transfusion-dependent aplastic anemia, which responded to treatment with prednisone on two occasions. The exacerbations of aplastic anemia were associated with lymphocytic proliferation which on one occasion had the characteristics of T-cell chronic lymphocytic leukemia. Though he had had mild lymphoproliferation for a number of years, he ultimately died with progressive diffuse lymphoid infiltration of the bone marrow and other organs. The simultaneous occurrence of the T-cell lymphoproliferation and aplastic anemia and their simultaneous response to therapy suggests that this may be a clinical example of T-lymphocyte mediated suppression of erythropoiesis.
Full Text
Duke Authors
Cited Authors
- Bodner, S; Cohen, HJ
Published Date
- November 1, 1981
Published In
Volume / Issue
- 11 / 3
Start / End Page
- 293 - 298
PubMed ID
- 6976120
International Standard Serial Number (ISSN)
- 0361-8609
Digital Object Identifier (DOI)
- 10.1002/ajh.2830110310
Language
- eng
Conference Location
- United States