Transient monoclonal immunoglobulin G with anti-dextran activity.


Journal Article

A patient with regional enteritis had received iron dextran for treatment of iron deficiency. Subsequently he developed a large (3.1 g/100 ml) IgG-K serum spike which had precipitin activity against dextran sulfate but not a variety of other antigens. There has been no evidence of multiple myeloma and the spike gradually disappeared spontaneously over the course of 2 years. We speculate that the monoclonal protein may have developed as a response to the iron dextran injections under the immunologic stress of a chronic inflammatory disease.

Full Text

Duke Authors

Cited Authors

  • Shimm, DS; Cohen, HJ

Published Date

  • 1978

Published In

Volume / Issue

  • 59 / 2

Start / End Page

  • 99 - 103

PubMed ID

  • 415480

Pubmed Central ID

  • 415480

International Standard Serial Number (ISSN)

  • 0001-5792

Digital Object Identifier (DOI)

  • 10.1159/000207755


  • eng

Conference Location

  • Switzerland