Substance P and adrenocorticotropic hormone do not affect T-lymphocyte adhesion to vascular endothelium or surface expression of adhesion receptors.

Journal Article

Substance P (SP) and adrenocorticotropic hormone (ACTH) are peptides that have been shown to have both neurological and immunological effects. Because of the demonstrated effects upon immune function, we examined the effects of these peptides on T-lymphocyte adhesion to vascular endothelium and surface adhesion receptor expression. Neither the adhesion assays nor the expression assays showed any statistically significant effect of SP (10 microM) or ACTH (1 microM) for any incubation period used. We conclude that, while SP and ACTH have a variety of immunomodulatory effects, direct modulation of T-lymphocyte adhesion to vascular endothelium is probably not one of them.

Full Text

Duke Authors

Cited Authors

  • Smart, BA; Rao, KM; Cohen, HJ

Published Date

  • February 1994

Published In

Volume / Issue

  • 16 / 2

Start / End Page

  • 137 - 149

PubMed ID

  • 7514158

International Standard Serial Number (ISSN)

  • 0192-0561

Language

  • eng

Conference Location

  • England