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Serum albumin in older persons: relationship with age and health status.

Publication ,  Journal Article
Salive, ME; Cornoni-Huntley, J; Phillips, CL; Guralnik, JM; Cohen, HJ; Ostfeld, AM; Wallace, RB
Published in: J Clin Epidemiol
March 1992

We analyzed data from 4115 persons aged 71 years and older who had blood drawn at a home visit in three communities to examine the cross-sectional distribution of serum albumin and correlates of hypoalbuminemia. Mean albumin was lower among older persons, from 41.6 g/l in men aged 71-74 years to 38.5 g/l in men 90 years or older, and from 41.1 g/l to 38.9 g/l in women of the same ages, respectively. Hypoalbuminemia (albumin less than 35 g/l) was observed in 3.1% of subjects. Hypoalbuminemia and lower serum albumin were independently associated with anemia, recent diagnosis of cancer, two or more limitations in activities of daily living, residence in a nursing home, heavy cigarette smoking (greater than 1 pack/day), and older age. A 10-year age increment was associated with 0.8 g/l lower serum albumin and odds ratio of 1.56 (95% CI 1.14, 2.13) for hypoalbuminemia after adjusting for demographic factors and health status. Characteristics associated with serum albumin may confound the reported relationship between serum albumin and mortality.

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Published In

J Clin Epidemiol

DOI

ISSN

0895-4356

Publication Date

March 1992

Volume

45

Issue

3

Start / End Page

213 / 221

Location

United States

Related Subject Headings

  • Smoking
  • Serum Albumin
  • Morbidity
  • Male
  • Longitudinal Studies
  • Humans
  • Health Status
  • Health Behavior
  • Female
  • Epidemiology
 

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Salive, M. E., Cornoni-Huntley, J., Phillips, C. L., Guralnik, J. M., Cohen, H. J., Ostfeld, A. M., & Wallace, R. B. (1992). Serum albumin in older persons: relationship with age and health status. J Clin Epidemiol, 45(3), 213–221. https://doi.org/10.1016/0895-4356(92)90081-w
Salive, M. E., J. Cornoni-Huntley, C. L. Phillips, J. M. Guralnik, H. J. Cohen, A. M. Ostfeld, and R. B. Wallace. “Serum albumin in older persons: relationship with age and health status.J Clin Epidemiol 45, no. 3 (March 1992): 213–21. https://doi.org/10.1016/0895-4356(92)90081-w.
Salive ME, Cornoni-Huntley J, Phillips CL, Guralnik JM, Cohen HJ, Ostfeld AM, et al. Serum albumin in older persons: relationship with age and health status. J Clin Epidemiol. 1992 Mar;45(3):213–21.
Salive, M. E., et al. “Serum albumin in older persons: relationship with age and health status.J Clin Epidemiol, vol. 45, no. 3, Mar. 1992, pp. 213–21. Pubmed, doi:10.1016/0895-4356(92)90081-w.
Salive ME, Cornoni-Huntley J, Phillips CL, Guralnik JM, Cohen HJ, Ostfeld AM, Wallace RB. Serum albumin in older persons: relationship with age and health status. J Clin Epidemiol. 1992 Mar;45(3):213–221.
Journal cover image

Published In

J Clin Epidemiol

DOI

ISSN

0895-4356

Publication Date

March 1992

Volume

45

Issue

3

Start / End Page

213 / 221

Location

United States

Related Subject Headings

  • Smoking
  • Serum Albumin
  • Morbidity
  • Male
  • Longitudinal Studies
  • Humans
  • Health Status
  • Health Behavior
  • Female
  • Epidemiology