Serum albumin in older persons: relationship with age and health status.

Journal Article (Journal Article)

We analyzed data from 4115 persons aged 71 years and older who had blood drawn at a home visit in three communities to examine the cross-sectional distribution of serum albumin and correlates of hypoalbuminemia. Mean albumin was lower among older persons, from 41.6 g/l in men aged 71-74 years to 38.5 g/l in men 90 years or older, and from 41.1 g/l to 38.9 g/l in women of the same ages, respectively. Hypoalbuminemia (albumin less than 35 g/l) was observed in 3.1% of subjects. Hypoalbuminemia and lower serum albumin were independently associated with anemia, recent diagnosis of cancer, two or more limitations in activities of daily living, residence in a nursing home, heavy cigarette smoking (greater than 1 pack/day), and older age. A 10-year age increment was associated with 0.8 g/l lower serum albumin and odds ratio of 1.56 (95% CI 1.14, 2.13) for hypoalbuminemia after adjusting for demographic factors and health status. Characteristics associated with serum albumin may confound the reported relationship between serum albumin and mortality.

Full Text

Duke Authors

Cited Authors

  • Salive, ME; Cornoni-Huntley, J; Phillips, CL; Guralnik, JM; Cohen, HJ; Ostfeld, AM; Wallace, RB

Published Date

  • March 1992

Published In

Volume / Issue

  • 45 / 3

Start / End Page

  • 213 - 221

PubMed ID

  • 1569418

International Standard Serial Number (ISSN)

  • 0895-4356

Digital Object Identifier (DOI)

  • 10.1016/0895-4356(92)90081-w


  • eng

Conference Location

  • United States