Tumor necrosis factor, natural killer activity and other measures of immune function and inflammation in elderly men with heart failure.

Journal Article (Journal Article)

OBJECTIVE: To determine the status of tumor necrosis factor (TNF) and other measures of immunity and inflammation in chronic heart failure (CHF) in the elderly. DESIGN: Comparative survey study of subjects with heart failure and age-matched controls. SETTINGS: University affiliated tertiary care VA Medical Center, Heart Failure Clinic. PATIENTS: Twenty men with New York Class II and III heart failure and 17 age-matched controls. INTERVENTIONS: None. MAIN OUTCOME MEASURE: Levels of lymphocyte mitogenesis, TNF, natural killer (NK) cell activity, elastase-alpha 1-antitrypsin (E/alpha) and cross-linked fibrin D-dimers (XDP). RESULTS: TNF levels (p = 0.27), NK activity (p = 0.56), and lymphocyte mitogenesis (p = 0.67) were similar in patients and controls. E/alpha levels were somewhat lower in CHF patients (p = 0.05) and XDP were similar (p = 0.59). However, TNF levels were significantly related to NK activity and to E/alpha activity in elderly men with heart failure but not controls. XDP were positively related to NK in heart failure patients but not controls. CONCLUSION: TNF and other measures of immune function and inflammation do not appear to be significantly elevated in elderly patients with heart failure of moderate severity. However, significant relationships exist between TNF, NK activity, XDP and E/alpha in the heart failure patients only, suggesting that immune activation and subclinical inflammation does exist in these patients.

Full Text

Duke Authors

Cited Authors

  • Prichett, G; Cohen, HJ; Rao, KM; Cobb, F; Sullivan, M; Currie, MS

Published Date

  • 1995

Published In

Volume / Issue

  • 41 / 1

Start / End Page

  • 45 - 56

PubMed ID

  • 7737534

International Standard Serial Number (ISSN)

  • 0304-324X

Digital Object Identifier (DOI)

  • 10.1159/000213661


  • eng

Conference Location

  • Switzerland