Meningeal mycosis fungoides: clinical and cellular characteristics.

Journal Article (Journal Article)

A patient with mycosis fungoides developed meningeal disease while his skin disease was in remission with systemic chemotherapy. His central nervous system involvement with mycosis fungoides was controlled with intrathecal methotrexate for 7 months. The proliferating cells recovered from the spinal fluid showed similarities to the Sézary cell by light and electron microscopy. Surface receptor sutudies suggested that these cells were lymphoid cells of thymic derivation. Although mycosis fungoides has been shown to spread to the central nervous system in autopsied cases, reports of clinical neurologic disease are rare, and in only one earlier report have malignant cells have been found in the spinal fluid. Thus, as in other lymphoproliferative disorders, prompt consideration of meningeal involvement in a patient exhibiting neurologic symptoms while in peripheral remission may allow earlier treatment of this complication.

Full Text

Duke Authors

Cited Authors

  • Hauch, TW; Shelbourne, JD; Cohen, HJ; Mason, D; Kremer, WB

Published Date

  • April 1, 1975

Published In

Volume / Issue

  • 82 / 4

Start / End Page

  • 499 - 505

PubMed ID

  • 1168035

International Standard Serial Number (ISSN)

  • 0003-4819

Digital Object Identifier (DOI)

  • 10.7326/0003-4819-82-4-499


  • eng

Conference Location

  • United States