Platinum-catalyzed hydrofunctionalization of unactivated alkenes with carbon, nitrogen and oxygen nucleophiles.
Published
Journal Article
The transition metal-catalyzed addition of the X-H bond of a carbon, nitrogen or oxygen nucleophile across the C[double bond]C bond of an unactivated alkene (hydrofunctionalization) represents an attractive, atom-economical approach to the synthesis of carbocyclic and heterocyclic molecules and for the elaboration of ethylene and 1-alkenes. We have developed a family of Pt(II)-catalyzed protocols for the inter- and intramolecular hydrofunctionalization of unactivated alkenes with a range of H-X nucleophiles including beta-diketones, indoles, amines, carboxamides and alcohols. These transformations display good functional group compatibility, low moisture sensitivity, and often good generality.
Full Text
Duke Authors
Cited Authors
- Liu, C; Bender, CF; Han, X; Widenhoefer, RA
Published Date
- September 2007
Published In
Start / End Page
- 3607 - 3618
PubMed ID
- 17728873
Pubmed Central ID
- 17728873
Electronic International Standard Serial Number (EISSN)
- 1364-548X
International Standard Serial Number (ISSN)
- 1359-7345
Digital Object Identifier (DOI)
- 10.1039/b615698c
Language
- eng