Gold(I)-catalyzed intramolecular enantioselective hydroarylation of allenes with indoles.

Published

Journal Article

Treatment of 2-allenyl indole 4 with a catalytic 1:2 mixture of [(S)-2]Au2Cl2 [(S)-2 = (S)-3,5-tBu-4-MeO-MeOBIPHEP] and AgBF4 in toluene at -10 degrees C for 17 h led to isolation of tetrahydrocarbazole 5 in 88% yield with 92% ee. The protocol was effective for the cyclization of terminally disubstituted allenes and for the formation of seven-membered rings.

Full Text

Duke Authors

Cited Authors

  • Liu, C; Widenhoefer, RA

Published Date

  • May 2007

Published In

Volume / Issue

  • 9 / 10

Start / End Page

  • 1935 - 1938

PubMed ID

  • 17428061

Pubmed Central ID

  • 17428061

Electronic International Standard Serial Number (EISSN)

  • 1523-7052

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol070483c

Language

  • eng