Renal transplantation in adults with thrombotic thrombocytopenic purpura/haemolytic-uraemic syndrome.

Journal Article (Journal Article)

BACKGROUND: Thrombotic thrombocytopenic purpura/haemolytic-uraemic syndrome (TTP/HUS) is a rare cause of renal failure in adults. There is little data concerning the outcome of adult patients who receive a renal transplant for TTP/HUS: METHODS: We have carried out a survey of 22 transplant centres in the USA to determine the outcome of patients who developed ESRD from TTP/HUS and latter received a renal transplant. RESULTS: Twelve of the 22 centres responded to our inquiry. Seven centres had not transplanted any patients with TTP/HUS, and five centres had transplanted a total of 24 grafts in 17 patients with TTP/HUS: Thirty-three per cent of patients demonstrated definite clinical and pathological evidence of recurrence of TTP/HUS: An additional 16% of patients demonstrated pathological evidence of possible recurrence of TTP/HUS in the absence of clinical manifestations. The overall 1-year graft survival rate was 42% and the 2-year graft survival rate was 35%. In our experience recurrence TTP/HUS was associated with universal graft failure. Although cyclosporin A does occasionally cause a thrombotic angiopathy in patients with no history of TTP/HUS, we found no evidence that it should be avoided in patients with a previous history of ESRD from TTP/HUS who subsequently receive a renal transplant. CONCLUSIONS: TTP/HUS frequently recurres in adults who receive a renal transplant, with a 2-year graft survival rate of 35%.

Full Text

Duke Authors

Cited Authors

  • Conlon, PJ; Brennan, DC; Pfaf, WW; Finn, WF; Gehr, T; Bollinger, RR; Smith, SR

Published Date

  • September 1996

Published In

Volume / Issue

  • 11 / 9

Start / End Page

  • 1810 - 1814

PubMed ID

  • 8918627

International Standard Serial Number (ISSN)

  • 0931-0509


  • eng

Conference Location

  • England