Effect of platelet-activating factor on hepatic capillary pressure in isolated dog liver.


Journal Article

We determined the effects of platelet-activating factor (PAF), a potent vasoactive autacoid phospholipid, on the capillary pressure and liver weight (Wt) in isolated canine livers perfused with blood bivascularly via the portal vein and hepatic artery. PAF (0.01-33 microg) administered intraportally produced dose-dependent increases in the hepatic capillary pressure, as assessed by triple vascular occlusion pressure (Pto), and Wt. An intraportal injection of 10 microg PAF produced increases in Pto by 10 mmHg and Wt by 35 g/100 g liver weight. This hepatic vasoconstriction was attributed to a threefold increase in the portal vein resistance and a fourfold increase in the hepatic vein resistance. The hepatic arterial resistance was not changed when PAF was arterially or intraportally injected. In conclusion, in isolated perfused dog livers, PAF increases the hepatic capillary pressure and liver weight due to contraction of both the portal vein and hepatic vein, but not the hepatic artery.

Full Text

Cited Authors

  • Wang, HG; Shibamoto, T; Koyama, S

Published Date

  • September 1997

Published In

Volume / Issue

  • 57 / 3

Start / End Page

  • 293 - 298

PubMed ID

  • 9384519

Pubmed Central ID

  • 9384519

Electronic International Standard Serial Number (EISSN)

  • 1532-2823

International Standard Serial Number (ISSN)

  • 0952-3278

Digital Object Identifier (DOI)

  • 10.1016/s0952-3278(97)90547-0


  • eng