Gene expression analysis of cardiovascular diseases: novel insights into biology and clinical applications.

Journal Article (Review)

Although the contribution of genetics to complex cardiovascular diseases such as atherosclerosis has been accepted for quite some time, full and detailed knowledge of the individual causative genes has been elusive. With the advent of genomic technologies and methods, the necessary tools are now available to begin pinpointing the genes that contribute to disease susceptibility and progression. One approach being applied extensively in candidate gene discovery is gene expression analysis of human and animal tissues using microarrays. The genes identified by these genomic studies provide valuable insight into disease biology and represent the initial steps toward the development of diagnostic tests and therapeutic strategies that will substantially improve human health. This paper highlights the progress that has been made in using gene expression analysis cardiovascular genomic research and the potential for applying these findings in clinical medicine.

Full Text

Duke Authors

Cited Authors

  • Seo, D; Ginsburg, GS; Goldschmidt-Clermont, PJ

Published Date

  • July 18, 2006

Published In

Volume / Issue

  • 48 / 2

Start / End Page

  • 227 - 235

PubMed ID

  • 16843168

Electronic International Standard Serial Number (EISSN)

  • 1558-3597

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2006.02.070

Language

  • eng

Conference Location

  • United States