High-density lipoprotein subfractions.


Journal Article (Review)

High-density lipoprotein (HDL) consists of a heterogeneous group of particles defined either by size or by apolipoprotein content. Subfractions of HDL appear to have distinct but interrelated metabolic functions, including facilitation of cholesteryl ester transfer to low- and very-low-density lipoproteins, modulation of triglyceride-rich particle catabolism, and, possibly, removal of cholesterol from peripheral tissues. Like HDL cholesterol, HDL subfractions are widely affected by a variety of factors. Subfractions also are markers for epidemiologic risk for coronary artery disease. Because they provide information about the physiologic processes of cholesterol metabolism, HDL subfractions are emerging as an increasingly important tool in the study of the relationship between lipids and cardiovascular disease.

Full Text

Duke Authors

Cited Authors

  • Silverman, DI; Ginsburg, GS; Pasternak, RC

Published Date

  • June 1, 1993

Published In

Volume / Issue

  • 94 / 6

Start / End Page

  • 636 - 645

PubMed ID

  • 8506891

Pubmed Central ID

  • 8506891

International Standard Serial Number (ISSN)

  • 0002-9343

Digital Object Identifier (DOI)

  • 10.1016/0002-9343(93)90217-d


  • eng

Conference Location

  • United States