Challenges in the phenotypic characterisation of patients in genetic studies of coronary artery disease.

Journal Article (Journal Article;Review)

Coronary artery disease and acute myocardial infarction are complex traits in which there has been recent research to identify the principal genes that engender susceptibility or provide protection. Although there has been exceptional progress in the technology, which now allows genotyping of hundreds of thousands of single-nucleotide polymorphisms in each individual, there remains a pattern of inconsistency in the studies performed to date, in part owing to the difficulties in defining cases and controls. In this paper, salient issues to facilitate research in this important field are reviewed.

Full Text

Duke Authors

Cited Authors

  • Luo, AK; Jefferson, BK; Garcia, MJ; Ginsburg, GS; Topol, EJ

Published Date

  • March 2007

Published In

Volume / Issue

  • 44 / 3

Start / End Page

  • 161 - 165

PubMed ID

  • 17158593

Pubmed Central ID

  • PMC2598022

Electronic International Standard Serial Number (EISSN)

  • 1468-6244

Digital Object Identifier (DOI)

  • 10.1136/jmg.2006.045732


  • eng

Conference Location

  • England