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Nitric oxide in the human respiratory cycle.

Publication ,  Journal Article
McMahon, TJ; Moon, RE; Luschinger, BP; Carraway, MS; Stone, AE; Stolp, BW; Gow, AJ; Pawloski, JR; Watke, P; Singel, DJ; Piantadosi, CA; Stamler, JS
Published in: Nat Med
July 2002

Interactions of nitric oxide (NO) with hemoglobin (Hb) could regulate the uptake and delivery of oxygen (O(2)) by subserving the classical physiological responses of hypoxic vasodilation and hyperoxic vasconstriction in the human respiratory cycle. Here we show that in in vitro and ex vivo systems as well as healthy adults alternately exposed to hypoxia or hyperoxia (to dilate or constrict pulmonary and systemic arteries in vivo), binding of NO to hemes (FeNO) and thiols (SNO) of Hb varies as a function of HbO(2) saturation (FeO(2)). Moreover, we show that red blood cell (RBC)/SNO-mediated vasodilator activity is inversely proportional to FeO(2) over a wide range, whereas RBC-induced vasoconstriction correlates directly with FeO(2). Thus, native RBCs respond to changes in oxygen tension (pO2) with graded vasodilator and vasoconstrictor activity, which emulates the human physiological response subserving O(2) uptake and delivery. The ability to monitor and manipulate blood levels of NO, in conjunction with O(2) and carbon dioxide, may therefore prove useful in the diagnosis and treatment of many human conditions and in the development of new therapies. Our results also help elucidate the link between RBC dyscrasias and cardiovascular morbidity.

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Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

July 2002

Volume

8

Issue

7

Start / End Page

711 / 717

Location

United States

Related Subject Headings

  • Vasodilation
  • Vasoconstriction
  • Respiratory System
  • Respiratory Mechanics
  • Oxygen
  • Nitric Oxide
  • Immunology
  • Hypoxia
  • Hyperoxia
  • Humans
 

Citation

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McMahon, T. J., Moon, R. E., Luschinger, B. P., Carraway, M. S., Stone, A. E., Stolp, B. W., … Stamler, J. S. (2002). Nitric oxide in the human respiratory cycle. Nat Med, 8(7), 711–717. https://doi.org/10.1038/nm718
McMahon, Timothy J., Richard E. Moon, Ben P. Luschinger, Martha S. Carraway, Anne E. Stone, Bryant W. Stolp, Andrew J. Gow, et al. “Nitric oxide in the human respiratory cycle.Nat Med 8, no. 7 (July 2002): 711–17. https://doi.org/10.1038/nm718.
McMahon TJ, Moon RE, Luschinger BP, Carraway MS, Stone AE, Stolp BW, et al. Nitric oxide in the human respiratory cycle. Nat Med. 2002 Jul;8(7):711–7.
McMahon, Timothy J., et al. “Nitric oxide in the human respiratory cycle.Nat Med, vol. 8, no. 7, July 2002, pp. 711–17. Pubmed, doi:10.1038/nm718.
McMahon TJ, Moon RE, Luschinger BP, Carraway MS, Stone AE, Stolp BW, Gow AJ, Pawloski JR, Watke P, Singel DJ, Piantadosi CA, Stamler JS. Nitric oxide in the human respiratory cycle. Nat Med. 2002 Jul;8(7):711–717.

Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

July 2002

Volume

8

Issue

7

Start / End Page

711 / 717

Location

United States

Related Subject Headings

  • Vasodilation
  • Vasoconstriction
  • Respiratory System
  • Respiratory Mechanics
  • Oxygen
  • Nitric Oxide
  • Immunology
  • Hypoxia
  • Hyperoxia
  • Humans