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Pharmacologic and sensorimotor components of satiation in cigarette smoking.

Publication ,  Journal Article
Rose, JE; Behm, FM; Westman, EC; Bates, JE; Salley, A
Published in: Pharmacol Biochem Behav
September 2003

To examine mechanisms underlying satiation in cigarette smoking, 18 smokers received intravenous (i.v.) nicotine, alone or in combination with denicotinized cigarette smoke. Nicotine was administered using programmed presentations of either pulsed injections or continuous infusions, with i.v. saline serving as a control. A high-nicotine cigarette smoke condition (usual brand) was also presented. During each of the six test sessions, subjects were allowed to puff on their usual brands of cigarette ad libitum while the programmed satiation conditions were in force. Administration of i.v. nicotine caused a small suppression of ad libitum smoking behavior; denicotinized smoke produced a significantly larger reduction, showing that short-term satiation is more dependent on the presentation of smoke than delivery of nicotine per se. However, denicotinized smoke alone did not have as much effect as puffs from the usual brands of cigarettes. The combination of i.v. nicotine and denicotinized smoke puffs produced equivalent satiation to that of the usual brand. Cigarette craving and negative affect were partially relieved by iv nicotine presentations as well as by denicotinized smoke, and again the combination of i.v. nicotine and denicotinized smoke approximated the effects of the usual brand. The results of this study underscore the importance of both sensorimotor aspects of smoking and the pharmacologic effects of nicotine in tobacco dependence.

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Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

September 2003

Volume

76

Issue

2

Start / End Page

243 / 250

Location

United States

Related Subject Headings

  • Substance Withdrawal Syndrome
  • Smoking Cessation
  • Smoking
  • Satiation
  • Nicotinic Agonists
  • Nicotine
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Injections, Intravenous
 

Citation

APA
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Rose, J. E., Behm, F. M., Westman, E. C., Bates, J. E., & Salley, A. (2003). Pharmacologic and sensorimotor components of satiation in cigarette smoking. Pharmacol Biochem Behav, 76(2), 243–250. https://doi.org/10.1016/j.pbb.2003.07.002
Rose, Jed E., Frederique M. Behm, Eric C. Westman, James E. Bates, and Al Salley. “Pharmacologic and sensorimotor components of satiation in cigarette smoking.Pharmacol Biochem Behav 76, no. 2 (September 2003): 243–50. https://doi.org/10.1016/j.pbb.2003.07.002.
Rose JE, Behm FM, Westman EC, Bates JE, Salley A. Pharmacologic and sensorimotor components of satiation in cigarette smoking. Pharmacol Biochem Behav. 2003 Sep;76(2):243–50.
Rose, Jed E., et al. “Pharmacologic and sensorimotor components of satiation in cigarette smoking.Pharmacol Biochem Behav, vol. 76, no. 2, Sept. 2003, pp. 243–50. Pubmed, doi:10.1016/j.pbb.2003.07.002.
Rose JE, Behm FM, Westman EC, Bates JE, Salley A. Pharmacologic and sensorimotor components of satiation in cigarette smoking. Pharmacol Biochem Behav. 2003 Sep;76(2):243–250.
Journal cover image

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

September 2003

Volume

76

Issue

2

Start / End Page

243 / 250

Location

United States

Related Subject Headings

  • Substance Withdrawal Syndrome
  • Smoking Cessation
  • Smoking
  • Satiation
  • Nicotinic Agonists
  • Nicotine
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Injections, Intravenous