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Distinct electric potentials in soma and neurite membranes.

Publication ,  Journal Article
Bedlack, RS; Wei, MD; Fox, SH; Gross, E; Loew, LM
Published in: Neuron
November 1994

Structurally similar voltage-dependent ion channels may behave differently in different locations along the surface of a neuron. A possible reason could be that channels experience nonuniform electrical potentials along the plasmalemma. Here, we map the electrical potentials along the membrane of differentiated N1E-115 neuroblastoma cells with a potential-sensitive dye. We find that the intramembrane potential gradient is indeed more positive in the membranes of neurites than in the membranes of somata. This is not attributable to differences in ion conductances or surface charge densities between the membranes of neurites and somata; instead, it can be explained by differences in lipid composition. The spatial variation in intramembrane electrical potential may help account for electrophysiological and functional differences between neurites and somata.

Duke Scholars

Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

November 1994

Volume

13

Issue

5

Start / End Page

1187 / 1193

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Neurons
  • Neurology & Neurosurgery
  • Neurites
  • Mice
  • Membrane Potentials
  • Membrane Lipids
  • In Vitro Techniques
  • Cholesterol
  • Cells, Cultured
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bedlack, R. S., Wei, M. D., Fox, S. H., Gross, E., & Loew, L. M. (1994). Distinct electric potentials in soma and neurite membranes. Neuron, 13(5), 1187–1193. https://doi.org/10.1016/0896-6273(94)90056-6
Bedlack, R. S., M. D. Wei, S. H. Fox, E. Gross, and L. M. Loew. “Distinct electric potentials in soma and neurite membranes.Neuron 13, no. 5 (November 1994): 1187–93. https://doi.org/10.1016/0896-6273(94)90056-6.
Bedlack RS, Wei MD, Fox SH, Gross E, Loew LM. Distinct electric potentials in soma and neurite membranes. Neuron. 1994 Nov;13(5):1187–93.
Bedlack, R. S., et al. “Distinct electric potentials in soma and neurite membranes.Neuron, vol. 13, no. 5, Nov. 1994, pp. 1187–93. Pubmed, doi:10.1016/0896-6273(94)90056-6.
Bedlack RS, Wei MD, Fox SH, Gross E, Loew LM. Distinct electric potentials in soma and neurite membranes. Neuron. 1994 Nov;13(5):1187–1193.
Journal cover image

Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

November 1994

Volume

13

Issue

5

Start / End Page

1187 / 1193

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Neurons
  • Neurology & Neurosurgery
  • Neurites
  • Mice
  • Membrane Potentials
  • Membrane Lipids
  • In Vitro Techniques
  • Cholesterol
  • Cells, Cultured