APOE genotype is a risk factor for neuropathy severity in diabetic patients.
This cross-sectional study tested the hypothesis that APOE genotype is a risk factor for diabetic neuropathy severity. A model with age, duration of diabetes, and APOE genotype was found to predict (p = 0.0083) severity on the Neuropathy Impairment Score in the Lower Limbs (NISLL). Considering genotype alone, patients with APOE 3/4 and 4/4 genotypes had 3 more NISLL points than patients with other genotypes. This impact on severity is equivalent to having 15 extra years of age or diabetes duration.
Bedlack, RS; Edelman, D; Gibbs, JW; Kelling, D; Strittmatter, W; Saunders, AM; Morgenlander, J
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