APOE genotype is a risk factor for neuropathy severity in diabetic patients.

Journal Article (Journal Article)

This cross-sectional study tested the hypothesis that APOE genotype is a risk factor for diabetic neuropathy severity. A model with age, duration of diabetes, and APOE genotype was found to predict (p = 0.0083) severity on the Neuropathy Impairment Score in the Lower Limbs (NISLL). Considering genotype alone, patients with APOE 3/4 and 4/4 genotypes had 3 more NISLL points than patients with other genotypes. This impact on severity is equivalent to having 15 extra years of age or diabetes duration.

Full Text

Duke Authors

Cited Authors

  • Bedlack, RS; Edelman, D; Gibbs, JW; Kelling, D; Strittmatter, W; Saunders, AM; Morgenlander, J

Published Date

  • March 25, 2003

Published In

Volume / Issue

  • 60 / 6

Start / End Page

  • 1022 - 1024

PubMed ID

  • 12654974

Electronic International Standard Serial Number (EISSN)

  • 1526-632X

Digital Object Identifier (DOI)

  • 10.1212/01.wnl.0000056689.50682.94


  • eng

Conference Location

  • United States