APOE genotype is a risk factor for neuropathy severity in diabetic patients.
Journal Article (Journal Article)
This cross-sectional study tested the hypothesis that APOE genotype is a risk factor for diabetic neuropathy severity. A model with age, duration of diabetes, and APOE genotype was found to predict (p = 0.0083) severity on the Neuropathy Impairment Score in the Lower Limbs (NISLL). Considering genotype alone, patients with APOE 3/4 and 4/4 genotypes had 3 more NISLL points than patients with other genotypes. This impact on severity is equivalent to having 15 extra years of age or diabetes duration.
Full Text
Duke Authors
- Bedlack, Richard Stanley
- Edelman, David Edward
- Morgenlander, Joel Charles
- Saunders, Ann Marie
- Strittmatter, Warren James
Cited Authors
- Bedlack, RS; Edelman, D; Gibbs, JW; Kelling, D; Strittmatter, W; Saunders, AM; Morgenlander, J
Published Date
- March 25, 2003
Published In
Volume / Issue
- 60 / 6
Start / End Page
- 1022 - 1024
PubMed ID
- 12654974
Pubmed Central ID
- 12654974
Electronic International Standard Serial Number (EISSN)
- 1526-632X
Digital Object Identifier (DOI)
- 10.1212/01.wnl.0000056689.50682.94
Language
- eng
Conference Location
- United States