Role of adhesion molecules and vascular endothelium in the pathogenesis of sickle cell disease.

Journal Article (Review)

A number of lines of evidence now support the hypothesis that vaso-occlusion and several of the sequelae of sickle cell disease (SCD) arise, at least in part, from adhesive interactions of sickle red blood cells, leukocytes, and the endothelium. Both experimental and genetic evidence provide support for the importance of these interactions. It is likely that future therapies for SCD might target one or more of these interactions.

Full Text

Duke Authors

Cited Authors

  • Telen, MJ

Published Date

  • 2007

Published In

Start / End Page

  • 84 - 90

PubMed ID

  • 18024614

Pubmed Central ID

  • 18024614

International Standard Serial Number (ISSN)

  • 1520-4391

Digital Object Identifier (DOI)

  • 10.1182/asheducation-2007.1.84


  • eng

Conference Location

  • United States