Role of adhesion molecules and vascular endothelium in the pathogenesis of sickle cell disease.
Journal Article (Review)
A number of lines of evidence now support the hypothesis that vaso-occlusion and several of the sequelae of sickle cell disease (SCD) arise, at least in part, from adhesive interactions of sickle red blood cells, leukocytes, and the endothelium. Both experimental and genetic evidence provide support for the importance of these interactions. It is likely that future therapies for SCD might target one or more of these interactions.
Full Text
Duke Authors
Cited Authors
- Telen, MJ
Published Date
- 2007
Published In
Start / End Page
- 84 - 90
PubMed ID
- 18024614
Pubmed Central ID
- 18024614
International Standard Serial Number (ISSN)
- 1520-4391
Digital Object Identifier (DOI)
- 10.1182/asheducation-2007.1.84
Language
- eng
Conference Location
- United States