Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria.

Journal Article (Journal Article)

Nitric oxide (NO) plays an important role in host resistance to infection with a variety of organisms. Two recent reports from Gabon and Gambia identified associations of malaria disease severity with the inducible NO synthase (NOS2) promoter G-954C and short allele (<11 repeats) pentanucleotide microsatellite polymorphisms, respectively. It was postulated that there would be a correlation of these polymorphisms with malaria disease severity and with measures of NO production in our cohort of Tanzanian children with malaria. In Tanzanian children, 15% were heterozygous or homozygous for the G-954C polymorphism, and 13% had the short-allele microsatellite polymorphism. There was no significant correlation of either polymorphism with disease severity or with measures of NO production and NOS2 expression. Black and white Americans differed significantly in the frequencies of these polymorphisms. The various association of these gene polymorphisms with malaria severity in different populations underscores the complexity of host resistance to malaria.

Full Text

Duke Authors

Cited Authors

  • Levesque, MC; Hobbs, MR; Anstey, NM; Vaughn, TN; Chancellor, JA; Pole, A; Perkins, DJ; Misukonis, MA; Chanock, SJ; Granger, DL; Weinberg, JB

Published Date

  • December 1999

Published In

Volume / Issue

  • 180 / 6

Start / End Page

  • 1994 - 2002

PubMed ID

  • 10558957

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1086/315140


  • eng

Conference Location

  • United States