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Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria.

Publication ,  Journal Article
Levesque, MC; Hobbs, MR; Anstey, NM; Vaughn, TN; Chancellor, JA; Pole, A; Perkins, DJ; Misukonis, MA; Chanock, SJ; Granger, DL; Weinberg, JB
Published in: J Infect Dis
December 1999

Nitric oxide (NO) plays an important role in host resistance to infection with a variety of organisms. Two recent reports from Gabon and Gambia identified associations of malaria disease severity with the inducible NO synthase (NOS2) promoter G-954C and short allele (<11 repeats) pentanucleotide microsatellite polymorphisms, respectively. It was postulated that there would be a correlation of these polymorphisms with malaria disease severity and with measures of NO production in our cohort of Tanzanian children with malaria. In Tanzanian children, 15% were heterozygous or homozygous for the G-954C polymorphism, and 13% had the short-allele microsatellite polymorphism. There was no significant correlation of either polymorphism with disease severity or with measures of NO production and NOS2 expression. Black and white Americans differed significantly in the frequencies of these polymorphisms. The various association of these gene polymorphisms with malaria severity in different populations underscores the complexity of host resistance to malaria.

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Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

December 1999

Volume

180

Issue

6

Start / End Page

1994 / 2002

Location

United States

Related Subject Headings

  • White People
  • Tanzania
  • Severity of Illness Index
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Nitric Oxide Synthase Type II
  • Nitric Oxide Synthase
  • Nitric Oxide
  • Nitrates
  • Microsatellite Repeats
 

Citation

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Levesque, M. C., Hobbs, M. R., Anstey, N. M., Vaughn, T. N., Chancellor, J. A., Pole, A., … Weinberg, J. B. (1999). Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria. J Infect Dis, 180(6), 1994–2002. https://doi.org/10.1086/315140
Levesque, M. C., M. R. Hobbs, N. M. Anstey, T. N. Vaughn, J. A. Chancellor, A. Pole, D. J. Perkins, et al. “Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria.J Infect Dis 180, no. 6 (December 1999): 1994–2002. https://doi.org/10.1086/315140.
Levesque MC, Hobbs MR, Anstey NM, Vaughn TN, Chancellor JA, Pole A, et al. Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria. J Infect Dis. 1999 Dec;180(6):1994–2002.
Levesque, M. C., et al. “Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria.J Infect Dis, vol. 180, no. 6, Dec. 1999, pp. 1994–2002. Pubmed, doi:10.1086/315140.
Levesque MC, Hobbs MR, Anstey NM, Vaughn TN, Chancellor JA, Pole A, Perkins DJ, Misukonis MA, Chanock SJ, Granger DL, Weinberg JB. Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria. J Infect Dis. 1999 Dec;180(6):1994–2002.
Journal cover image

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

December 1999

Volume

180

Issue

6

Start / End Page

1994 / 2002

Location

United States

Related Subject Headings

  • White People
  • Tanzania
  • Severity of Illness Index
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Nitric Oxide Synthase Type II
  • Nitric Oxide Synthase
  • Nitric Oxide
  • Nitrates
  • Microsatellite Repeats