A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production.

Published

Journal Article

Interleukin-12 (IL-12) is an important regulatory cytokine in infection and immunity. Administration of IL-12 may reduce complications of severe malaria in rodents. Polymorphisms in IL12B, the gene encoding the IL-12 p40 subunit, influence the secretion of IL-12 and susceptibility to Type 1 diabetes. We therefore investigated whether IL12B polymorphisms may affect the outcome of severe malaria. Homozygosity for a polymorphism in the IL12B promoter was associated with increased mortality in Tanzanian children having cerebral malaria but not in Kenyan children with severe malaria. Furthermore, homozygotes for the IL12B promotor polymorphism had decreased production of nitric oxide, which is in part regulated by IL-12 activity. These studies suggest that IL12B polymorphisms, via regulation of IL-12 production, may influence the outcome of malaria infection in at least one African population.

Full Text

Duke Authors

Cited Authors

  • Morahan, G; Boutlis, CS; Huang, D; Pain, A; Saunders, JR; Hobbs, MR; Granger, DL; Weinberg, JB; Peshu, N; Mwaikambo, ED; Marsh, K; Roberts, DJ; Anstey, NM

Published Date

  • November 2002

Published In

Volume / Issue

  • 3 / 7

Start / End Page

  • 414 - 418

PubMed ID

  • 12424623

Pubmed Central ID

  • 12424623

International Standard Serial Number (ISSN)

  • 1466-4879

Digital Object Identifier (DOI)

  • 10.1038/sj.gene.6363909

Language

  • eng

Conference Location

  • England