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A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production.

Publication ,  Journal Article
Morahan, G; Boutlis, CS; Huang, D; Pain, A; Saunders, JR; Hobbs, MR; Granger, DL; Weinberg, JB; Peshu, N; Mwaikambo, ED; Marsh, K; Roberts, DJ ...
Published in: Genes Immun
November 2002

Interleukin-12 (IL-12) is an important regulatory cytokine in infection and immunity. Administration of IL-12 may reduce complications of severe malaria in rodents. Polymorphisms in IL12B, the gene encoding the IL-12 p40 subunit, influence the secretion of IL-12 and susceptibility to Type 1 diabetes. We therefore investigated whether IL12B polymorphisms may affect the outcome of severe malaria. Homozygosity for a polymorphism in the IL12B promoter was associated with increased mortality in Tanzanian children having cerebral malaria but not in Kenyan children with severe malaria. Furthermore, homozygotes for the IL12B promotor polymorphism had decreased production of nitric oxide, which is in part regulated by IL-12 activity. These studies suggest that IL12B polymorphisms, via regulation of IL-12 production, may influence the outcome of malaria infection in at least one African population.

Duke Scholars

Published In

Genes Immun

DOI

ISSN

1466-4879

Publication Date

November 2002

Volume

3

Issue

7

Start / End Page

414 / 418

Location

England

Related Subject Headings

  • Tanzania
  • Protein Subunits
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Plasmodium
  • Nitric Oxide
  • Molecular Sequence Data
  • Malaria, Cerebral
  • Kenya
  • Interleukin-12 Subunit p40
 

Citation

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Morahan, G., Boutlis, C. S., Huang, D., Pain, A., Saunders, J. R., Hobbs, M. R., … Anstey, N. M. (2002). A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production. Genes Immun, 3(7), 414–418. https://doi.org/10.1038/sj.gene.6363909
Morahan, G., C. S. Boutlis, D. Huang, A. Pain, J. R. Saunders, M. R. Hobbs, D. L. Granger, et al. “A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production.Genes Immun 3, no. 7 (November 2002): 414–18. https://doi.org/10.1038/sj.gene.6363909.
Morahan, G., et al. “A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production.Genes Immun, vol. 3, no. 7, Nov. 2002, pp. 414–18. Pubmed, doi:10.1038/sj.gene.6363909.
Morahan G, Boutlis CS, Huang D, Pain A, Saunders JR, Hobbs MR, Granger DL, Weinberg JB, Peshu N, Mwaikambo ED, Marsh K, Roberts DJ, Anstey NM. A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production. Genes Immun. 2002 Nov;3(7):414–418.

Published In

Genes Immun

DOI

ISSN

1466-4879

Publication Date

November 2002

Volume

3

Issue

7

Start / End Page

414 / 418

Location

England

Related Subject Headings

  • Tanzania
  • Protein Subunits
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Plasmodium
  • Nitric Oxide
  • Molecular Sequence Data
  • Malaria, Cerebral
  • Kenya
  • Interleukin-12 Subunit p40