Tumor cell killing by phorbol ester--differentiated human leukemia cells.

Journal Article (Journal Article)

The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate causes differentiation of cells of the human leukemia cell line HL60 to nondividing macrophage-like cells. These differentiated cells are cytotoxic for tumor cells (including parent, untreated HL60 cells) in vitro. Agents that induce this desirable differentiation to nondividing, antitumor effector cells may be useful in the experimental treatment of leukemia.

Full Text

Duke Authors

Cited Authors

  • Weinberg, JB

Published Date

  • August 7, 1981

Published In

Volume / Issue

  • 213 / 4508

Start / End Page

  • 655 - 657

PubMed ID

  • 7196085

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.7196085


  • eng

Conference Location

  • United States