Tumor cell killing by phorbol ester--differentiated human leukemia cells.
Journal Article (Journal Article)
The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate causes differentiation of cells of the human leukemia cell line HL60 to nondividing macrophage-like cells. These differentiated cells are cytotoxic for tumor cells (including parent, untreated HL60 cells) in vitro. Agents that induce this desirable differentiation to nondividing, antitumor effector cells may be useful in the experimental treatment of leukemia.
Full Text
Duke Authors
Cited Authors
- Weinberg, JB
Published Date
- August 7, 1981
Published In
Volume / Issue
- 213 / 4508
Start / End Page
- 655 - 657
PubMed ID
- 7196085
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.7196085
Language
- eng
Conference Location
- United States