Tumor cell killing by phorbol ester--differentiated human leukemia cells.

Journal Article

The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate causes differentiation of cells of the human leukemia cell line HL60 to nondividing macrophage-like cells. These differentiated cells are cytotoxic for tumor cells (including parent, untreated HL60 cells) in vitro. Agents that induce this desirable differentiation to nondividing, antitumor effector cells may be useful in the experimental treatment of leukemia.

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Duke Authors

Weinberg, Joe Brice

Cited Authors

Weinberg, JB

Published Date

August 7, 1981

Published In

Science (New York, N.Y.)

Volume / Issue

213 / 4508

Start / End Page

655 - 657

PubMed ID

7196085

International Standard Serial Number (ISSN)

0036-8075

Language

Conference Location

United States