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Nitric oxide production and mononuclear cell nitric oxide synthase activity in malaria-tolerant Papuan adults.

Publication ,  Journal Article
Boutlis, CS; Tjitra, E; Maniboey, H; Misukonis, MA; Saunders, JR; Suprianto, S; Weinberg, JB; Anstey, NM
Published in: Infect Immun
July 2003

Individuals living in regions of intense malaria transmission exhibit natural immunity that allows them to be without fever and other symptoms for most of the time despite frequent parasitization. Although this tolerance of parasitemia appears to be more effective in children than in adults (as evidenced by lower parasitemia fever thresholds with age), adults do exhibit a degree of tolerance but the mechanism(s) underlying this are unclear. Asymptomatic malaria-exposed children have higher levels of nitric oxide (NO) than children with severe disease, and NO has been proposed as a mediator of malarial tolerance. However, the ability of highly malaria-exposed asymptomatic adults to generate high-level basal NO is unknown, as is the relationship between NO and malaria tolerance in adults. The relationship between NO and malaria parasitemia was therefore determined in asymptomatic adults from Papua, Indonesia. Adults with Plasmodium falciparum parasitemia had markedly increased basal systemic NO production relative to aparasitemic Papuan controls, who in turn produced more NO than healthy controls from a region without malaria. Immunoglobulin E levels were universally elevated in malaria-exposed Papuan subjects, suggesting that the prevalence of intestinal parasitosis may be high and that nonmalarial infection may also contribute to high basal NO production. Basal peripheral blood mononuclear cell (PBMC) NO synthase activity was elevated in Papuans but poorly correlated with systemic NO production, suggesting that NO production in this setting arises not only from PBMCs but also from other tissue and cellular sources. NO production was associated with and may contribute to malaria tolerance in Papuan adults.

Duke Scholars

Published In

Infect Immun

DOI

ISSN

0019-9567

Publication Date

July 2003

Volume

71

Issue

7

Start / End Page

3682 / 3689

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Promoter Regions, Genetic
  • Parasitemia
  • Nitric Oxide Synthase Type II
  • Nitric Oxide Synthase
  • Nitric Oxide
  • Microbiology
  • Male
  • Malaria
  • Leukocytes, Mononuclear
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Boutlis, C. S., Tjitra, E., Maniboey, H., Misukonis, M. A., Saunders, J. R., Suprianto, S., … Anstey, N. M. (2003). Nitric oxide production and mononuclear cell nitric oxide synthase activity in malaria-tolerant Papuan adults. Infect Immun, 71(7), 3682–3689. https://doi.org/10.1128/IAI.71.7.3682-3689.2003
Boutlis, Craig S., Emiliana Tjitra, Helena Maniboey, Mary A. Misukonis, Jocelyn R. Saunders, Sri Suprianto, J Brice Weinberg, and Nicholas M. Anstey. “Nitric oxide production and mononuclear cell nitric oxide synthase activity in malaria-tolerant Papuan adults.Infect Immun 71, no. 7 (July 2003): 3682–89. https://doi.org/10.1128/IAI.71.7.3682-3689.2003.
Boutlis CS, Tjitra E, Maniboey H, Misukonis MA, Saunders JR, Suprianto S, et al. Nitric oxide production and mononuclear cell nitric oxide synthase activity in malaria-tolerant Papuan adults. Infect Immun. 2003 Jul;71(7):3682–9.
Boutlis, Craig S., et al. “Nitric oxide production and mononuclear cell nitric oxide synthase activity in malaria-tolerant Papuan adults.Infect Immun, vol. 71, no. 7, July 2003, pp. 3682–89. Pubmed, doi:10.1128/IAI.71.7.3682-3689.2003.
Boutlis CS, Tjitra E, Maniboey H, Misukonis MA, Saunders JR, Suprianto S, Weinberg JB, Anstey NM. Nitric oxide production and mononuclear cell nitric oxide synthase activity in malaria-tolerant Papuan adults. Infect Immun. 2003 Jul;71(7):3682–3689.

Published In

Infect Immun

DOI

ISSN

0019-9567

Publication Date

July 2003

Volume

71

Issue

7

Start / End Page

3682 / 3689

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Promoter Regions, Genetic
  • Parasitemia
  • Nitric Oxide Synthase Type II
  • Nitric Oxide Synthase
  • Nitric Oxide
  • Microbiology
  • Male
  • Malaria
  • Leukocytes, Mononuclear